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HomeProduct name listElemicin

Elemicin

  • CAS NO.:487-11-6
  • Empirical Formula: C12H16O3
  • Molecular Weight: 208.25
  • MDL number: MFCD01656688
  • EINECS: 207-649-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 15:53:33
Elemicin Structural

What is Elemicin?

Description

Elemicin is a trioxygenated phenylpropane that has been found in A. dracunculus. It is active against S. aureus, B. subtilis, and C. albicans (MICs = 600, 2,500, and 1,000 mg/L, respectively) but not E. coli, K. pneumoniae, P. aeruginosa (MICs = >8,000 mg/L for all), or L. monocytogenes (MIC = >3,000 mg/L). Elemicin is toxic to mice following metabolic activation to 1’-hydroxyelemicin by the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. It increases plasma and hepatic triglyceride levels, decreases stearoyl-CoA desaturase 1 (Scd1) expression, and induces hepatomegaly in mice when administered at a dose of 500 mg/kg per day for three weeks.

Chemical properties

Clear Colorless Oil

The Uses of Elemicin

A constituent of the essential oil of nutmeg and is responsible for the psychoactive effects of nutmeg. Also a minor constituent of the oleoresin and essential oil of Manila elemi (Canarium luzonicum). Exhibits anticholinergic-like effects in humans.

Definition

ChEBI: Elemicin is an olefinic compound.

What are the applications of Application

Elemicin is a constituent of the essential oil of nutmeg

Synthesis

Prod. :
1) by isolation from Elemi oil (high-boiling fractions).
2) from Dimcthylpyrogallol plus Allyl bromide, via 2,6-Dimethyl pyrogallol allylether. This is heated in a Claisen-rearrangement reaction to yield 4-Hydroxy-3,5-dimethoxy allylbenzene. The latter is methylated to yield Elemicine.
3) From Eugenol via 5-Hydroxyeugenol.

Properties of Elemicin

Boiling point: 152-156 °C
Density  1.0630 g/cm3
storage temp.  Amber Vial, -20°C Freezer
solubility  Chloroform (Slightly), Ethyl Acetate (Slightly)
form  Oil
color  Colourless
Odor at 100.00 %. spice flower
Stability: Light Sensitive
NIST Chemistry Reference Benzene, 1,2,3-trimethoxy-5-(2-propenyl)-(487-11-6)

Safety information for Elemicin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Elemicin

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