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HomeProduct name listEHT1864

EHT1864

Synonym(s):5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride

EHT1864 Structural

What is EHT1864?

The Uses of EHT1864

EHT 1864 is an inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively. It can reverse transformation of NIH 3T3 fibroblasts caused by constitutively activated Rac1, as well as Rac-dependent transformation caused by Tiam1 or Ras. EHT 1864 inhibits APP processing by γ-secretase, reducing Αβ40 and Αβ42 accumulation. It blocks breast cancer cell invasion in a collagen matrix assay and, at 10 μM, increases the size but decreases the density of dendritic spines of hippocampal neurons in culture.

The Uses of EHT1864

EHT 1864 is a potent Rac family GTPase inhibitor.

The Uses of EHT1864

EHT 1864 has been used to study the regulation of the adapter protein dishevelled-1 ubiquitylation by Rac1 activity.

What are the applications of Application

EHT 1864 is an antiproliferative inhibitor of Rac family GTPases, directly binding to Rac1, Rac1b, Rac2, and Rac3.

Biological Activity

Inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (K D values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β -amyloid peptide production in vivo .

Biochem/physiol Actions

EHT 1864 inhibits Rac function. It prevents Aβ40 and Aβ42 production in vitro without direct inhibition of g-secretase.

storage

Store at +4°C

References

[1] shutes a, onesto c, picard v, et al. specificity and mechanism of action of eht 1864, a novel small molecule inhibitor of rac family small gtpases. journal of biological chemistry, 2007, 282(49): 35666-35678.

Properties of EHT1864

Melting point: >195°C (dec.)
storage temp.  2-8°C
solubility  H2O: soluble10mg/mL, clear
form  powder
color  white to beige
CAS DataBase Reference 754240-09-0

Safety information for EHT1864

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for EHT1864

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