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HomeProduct name listE-64C

E-64C

Synonym(s):(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane

E-64C Structural

What is E-64C?

Description

E-64c is an active metabolite of the protease inhibitor E-64d . E-64c inhibits the cysteine proteases cathepsin B, cathepsin H, and papain but not the serine proteases trypsin, chymotrypsin, or elastase. It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease when used at concentrations ranging from 0.1 to 1 mg/ml. E-64c reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) surface glycoprotein, also known as the spike glycoprotein, in a concentration-dependent manner.

The Uses of E-64C

E-64c is a cysteine protease inhibitor used for detecting autophagy in plants.

What are the applications of Application

E-64-c is an effective synthetic calpain inhibitor

Definition

ChEBI: E-64c is a leucine derivative.

Properties of E-64C

storage temp.  Sealed in dry,Store in freezer, under -20°C
solubility  ≥31.4 mg/mL in DMSO; insoluble in H2O; ≥111.8 mg/mL in EtOH
form  White to off-white solid
color  White to off-white

Safety information for E-64C

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for E-64C

InChIKey SCMSYZJDIQPSDI-SRVKXCTJSA-N

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