E-4031

Synonym(s):N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride

CAS NO.：113559-13-0
Empirical Formula: C21H33Cl2N3O5S
Molecular Weight: 510.47
MDL number: MFCD00889193
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is E-4031?

The Uses of E-4031

E-4031 has been used as:

human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies
IKr blocker in rat ventricular myocytes

What are the applications of Application

E-4031 dihydrochloride is a K+ channel blocker that spawned a class of antiarrhythmic molecules

Biological Activity

Selective blocker of hERG K + channels; inhibits the rapid delayed-rectifier K + current (I Kr ). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na + or Ca 2+ inward currents. Class III antiarrhythmic agent.

Biochem/physiol Actions

E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation. E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits. An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.