DULCITOL

Synonym(s):5,6-Benzoflavone;beta-Naphthoflavone;BNF

CAS NO.：6051-87-2
Empirical Formula: C19H12O2
Molecular Weight: 272.3
MDL number: MFCD00004986
EINECS: 227-958-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-12 15:22:20

What is DULCITOL?

Chemical properties

SLIGHTLY BEIGE CRYSTALLINE POWDER

The Uses of DULCITOL

beta-Naphthoflavone is a Cytochrome P450 enzyme system inducer. It can also be used in biological study of novel dual-color luciferase reporter assay for simultaneous detection of estrogen and aryl hydrocarbon receptor activation.

What are the applications of Application

β-Naphthoflavone is a Cytochrome P450 enzyme system inducer

Definition

ChEBI: An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.

General Description

β-Naphthoflavone is a polyaromatic hydrocarbon.

Biochem/physiol Actions

β-Naphthoflavone (BNF) is an exogenous ligand for aryl hydrocarbon receptor (AhR) in humans. It is an inducer of phase I detoxification enzymes (CYPs) and phase II enzymes (UDP-GTs) and NAD(P)H-dependent quinone oxyreductase-1(NQO1). It also induces cytochrome P450 (Cyp1a). BNF represses the expression of Duchenne muscular dystrophy gene, dystrophin (Dp)71 by altering the binding of the transcription factors.

Properties of DULCITOL

Melting point:	164-166 °C (lit.)
Boiling point:	275-280 °C (1 mmHg)
Density	1.1382 (rough estimate)
refractive index	1.5510 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly, Heated)
form	Crystalline Powder
color	yellow to tan
BRN	18991
CAS DataBase Reference	6051-87-2(CAS DataBase Reference)

Safety information for DULCITOL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.