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HomeProduct name listDROFENINE HYDROCHLORIDE

DROFENINE HYDROCHLORIDE

  • CAS NO.:548-66-3
  • Empirical Formula: C20H32ClNO2
  • Molecular Weight: 353.93
  • MDL number: MFCD00034983
  • EINECS: 208-954-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
DROFENINE HYDROCHLORIDE Structural

What is DROFENINE HYDROCHLORIDE?

Originator

Trasentine A,Ciba

The Uses of DROFENINE HYDROCHLORIDE

Spasmolytic

The Uses of DROFENINE HYDROCHLORIDE

Drofenine is a widely used anticholinergic drug. It acts on smooth muscle to stop muscle spasms.

Manufacturing Process

17.4 parts of diphenylacetic acid 2-(diethylamino)ethyl ester were solved in 200 parts of acetic acid and hydrogenated over platinum catalyst. After the calculated volume of hydrogen was passed, the catalyst was filtered off and the solvent was removed to dryness. Ether, water and a potassium carbonate solution were added to the remaining oil and were thoroughly shaken. The ether layer was washed with water and dried over potassium carbonate. The solvent was removed, the remaining oil was distilled in vacuum to give 2- (diethylamino)ethyl α-phenylcyclohexaneacetate; BP 150°-160°C/0.2 mm Hg.
In practice it is usually used as hydrochloride.

Therapeutic Function

Spasmolytic

Properties of DROFENINE HYDROCHLORIDE

Melting point: 145-147°
storage temp.  2-8°C
solubility  Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Sligh
form  Solid
color  White to Off-White

Safety information for DROFENINE HYDROCHLORIDE

Computed Descriptors for DROFENINE HYDROCHLORIDE

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