DPO-1
Synonym(s):(+)-Neomenthyl diphenylphosphine oxide;(1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]diphenyl-phosphine oxide
- CAS NO.:43077-30-1
- Empirical Formula: C22H29OP
- Molecular Weight: 340.44
- MDL number: MFCD09038567
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:51:00
What is DPO-1?
What are the applications of Application
DPO-1 is a blocker of Kv1.5 channel and IKur ultra rapid delayed rectifier potassium current
Definition
ChEBI: [[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene is a monoterpenoid.
Biological Activity
Blocker of I Kur ultrarapid delayed rectifier potassium current and K V 1.5 channels (IC 50 = 0.31 μ M for rK V 1.5). Displays selectivity for inhibition of I Kur over I to (8-fold), I K1 , I Kr and I Ks (20-fold) in native myocytes and selectivity for rat recombinant K V 1.5 over K V 3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.
storage
Store at +4°C
Properties of DPO-1
storage temp. | Store at +4°C |
solubility | DMSO: soluble2mg/mL, clear (warmed) |
form | needles |
color | white |
Safety information for DPO-1
Computed Descriptors for DPO-1
New Products
(R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin F Tubulysin B Tubulysin H 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 4,4-DIFLUOROPIPERIDINE 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE CYCLOBUTYLAMINE HYDROCHLORIDE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2,2-Difluoropropylamine hydrochloride Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 1-(2,3-Dihydro- benzofuran-5-yl) -ethanone 4-(2-fluoro-4- nitrophenyl) thiomorpholine Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate 7-Methoxyquinoline-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
Cyclohexyldiphenylphosphine
DPO-1
(S)-(+)-NEOMENTHYLDIPHENYLPHOSPHINE
ISOPROPYLDIPHENYLPHOSPHINE OXIDE, 97
DIMETHYLOCTYLPHOSPHINE OXIDE, ANAGRADE?
CYCLOHEXYLDIPHENYLPHOSPHINE OXIDE
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