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HomeProduct name listDPO-1

DPO-1

Synonym(s):(+)-Neomenthyl diphenylphosphine oxide;(1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]diphenyl-phosphine oxide

DPO-1 Structural

What is DPO-1?

What are the applications of Application

DPO-1 is a blocker of Kv1.5 channel and IKur ultra rapid delayed rectifier potassium current

Definition

ChEBI: [[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene is a monoterpenoid.

Biological Activity

Blocker of I Kur ultrarapid delayed rectifier potassium current and K V 1.5 channels (IC 50 = 0.31 μ M for rK V 1.5). Displays selectivity for inhibition of I Kur over I to (8-fold), I K1 , I Kr and I Ks (20-fold) in native myocytes and selectivity for rat recombinant K V 1.5 over K V 3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.

storage

Store at +4°C

Properties of DPO-1

storage temp.  Store at +4°C
solubility  DMSO: soluble2mg/mL, clear (warmed)
form  needles
color  white

Safety information for DPO-1

Computed Descriptors for DPO-1

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