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HomeProduct name listDocarpamine

Docarpamine

Docarpamine Structural

What is Docarpamine?

Description

Docarpamine is a cardiostimulant with diuretic activity launched in Japan for the treatment of circulatory insufficiency. It is an orally effective peripheral dopamine prodrug that is well absorbed from the gastrointestinal tract and converted to dopamine in vivo, which exerts renal vasodilatory and natriuretic effects by activating renal dopamine (DA1) receptors, and a positive inotropic effect by activating cardiac β1-receptors. It has been reported to be effective in treating patients with acute heart failure, shock and acute renal failure.

Originator

Tanabe Seiyaku (Japan)

The Uses of Docarpamine

Docarpamine maybe a usefule alternative to intravenous dopamine after cardiac surgery.

Definition

ChEBI: Docarpamine is an organic molecular entity.

brand name

Tanadopa

Properties of Docarpamine

Melting point: 85-90°; mp 105-108° (Nishiyama, 1992)
Boiling point: 731.0±60.0 °C(Predicted)
alpha  D20 -15.6° (c = 2 in methanol)
Density  1.222±0.06 g/cm3(Predicted)
pka 14.51±0.46(Predicted)

Safety information for Docarpamine

Computed Descriptors for Docarpamine

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