DL-Histidine
Synonym(s):(S)-2-Amino-3-(4-imidazolyl)propionic acid;(±)-2-Amino-3-(4-imidazolyl)propionic acid;L -Histidine;NSC 137773
- CAS NO.：4998-57-6
- Empirical Formula: C6H9N3O2
- Molecular Weight: 155.15
- MDL number: MFCD00005208
- EINECS: 225-660-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-03 18:47:13
What is DL-Histidine?
Chemical properties
white to slightly yellow crystalline powder
The Uses of DL-Histidine
DL-Histidine has been used to study the fouling behaviour of polyethersulfone ultrafiltration membranes made with different PVP (polyvinylpyrrolidone).
The Uses of DL-Histidine
histidine is a skin-conditioning amino acid.
Definition
ChEBI: An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.
Synthesis Reference(s)
Journal of the American Chemical Society, 67, p. 502, 1945 DOI: 10.1021/ja01219a513
Chemical and Pharmaceutical Bulletin, 35, p. 3447, 1987
Biochem/physiol Actions
L-Histidine is involved in the one-carbon unit metabolism. It is associated with protein methylation. L-Histidine is a part of hemoglobin structure and function. L-Histidine is a component of dipeptides with antioxidative property. Histidine serves as a precursor for the formation of histamine, which is associated with allergic responses. Urocanic acid, an immune response modulator in skin is also biosynthesised from histidine.
Properties of DL-Histidine
| Melting point: | 273 °C (dec.)(lit.) |
| Boiling point: | 278.95°C (rough estimate) |
| Density | 1.3092 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | 0.5 M HCl: soluble |
| form | powder to crystal |
| pka | 1.8(at 25℃) |
| color | White to Almost white |
| Merck | 14,4720 |
| BRN | 7800 |
| CAS DataBase Reference | 4998-57-6(CAS DataBase Reference) |
| EPA Substance Registry System | Histidine (4998-57-6) |
Safety information for DL-Histidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DL-Histidine
New Products
(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin I Tubulysin B Tubulysin C 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 4-(Benzyloxy)-3-bromophenylacetic Acid 2,2-Difluoropropylamine hydrochloride tetrahydro-4-methyl-2H-pyran Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH 1-tosyl-3-(R)-(-)- hydroxypyrrolidine 1-(2,3-Dihydro- benzofuran-5-yl) -ethanone Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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