DL-3-Hydroxybutyric acid sodium salt

Synonym(s):(±)-3-Hydroxybutanoic acid sodium salt;(±)-3-Hydroxybutyric acid sodium salt

CAS NO.：150-83-4
Empirical Formula: C4H7NaO3
Molecular Weight: 126.09
MDL number: MFCD00016716
EINECS: 205-774-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-31 18:15:48

DL-3-Hydroxybutyric acid sodium salt Structural

What is DL-3-Hydroxybutyric acid sodium salt?

Chemical properties

white crystalline powder

The Uses of DL-3-Hydroxybutyric acid sodium salt

Optically active 3-hydroxybutyric acids are key intermediates of the biosynthesis and metabolism of fatty acids and exist widely in biological systems.

The Uses of DL-3-Hydroxybutyric acid sodium salt

DL-3-Hydroxybutyric acid sodium salt has been used in a study to understand the effect of butyrate on fibroblast growth factor 21 (FGF21), which is involved in fatty acid ?-oxidation in liver. It may be used in the preparation of poly(3-hydroxybutyrate).

What are the applications of Application

DL-3-Hydroxybutyric acid, sodium salt is a useful biochemcial for proteomics research

Definition

ChEBI: An organic sodium salt resulting from the replacement of the proton from the carboxy group of 3-hydroxybutyric acid by a sodium ion.

What are the applications of Application

DL-β-Hydroxybutyric acid sodium salt has been used:
as a standard for quantifying blood plasma and milk β-hydroxybutyric acid in Danish Jersey cows.
to investigate its anticonvulsant effects in epilepsy induced rats.
to induce hyperketonemia in Holstein dairy cows.

Biological Functions

Neuroprotective compound in experimental models of neurodegenerative diseases. Shown to be oxidized as an energetic substrate in the brain during starvation. May inhibit brain glucose oxidation, which may account for the suppression of hepatic glucose production observed after administration of ketone bodies in humans.

Biochem/physiol Actions

β-Hydroxybutyric acid is a ketone body present in the rumen epithelium of liver cells. Its interconversion to acetoacetate influences the acid-base balance and is coupled NADH generation from (nicotinamide adenine dinucleotide) NAD+, measured fluorimetrically. A high plasma level of β-hydroxybutyric acid is implicated in diabetic ketoacidosis. It traverses the blood-brain barrier as a monocarboxylic acid. β-Hydroxybutyric acid may play a protective role in dopaminergic neurodegeneration in Parkinson′s disease model. β-Hydroxybutyric acid is a ligand for G protein-coupled receptor(GPR109A) and favors inhibition of secretion, transcription and translation of growth hormone (GH) and prolactin (PRL) gene in cow anterior pituitary cells (DCAPCs).

Properties of DL-3-Hydroxybutyric acid sodium salt

Melting point:	167-170 °C
storage temp.	2-8°C
solubility	Methanol (Slightly, Sonicated), Water (Slightly)
form	Crystalline Powder
color	White
Sensitive	Hygroscopic
BRN	4824866
Stability:	Hygroscopic
InChI	InChI=1S/C4H8O3.Na/c1-3(5)2-4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1
CAS DataBase Reference	150-83-4(CAS DataBase Reference)

Safety information for DL-3-Hydroxybutyric acid sodium salt

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.