DL-2-Hydroxybutyric Acid
- CAS NO.:600-15-7
- Empirical Formula: C4H8O3
- Molecular Weight: 104.1
- MDL number: MFCD00070502
- EINECS: 209-985-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:37
What is DL-2-Hydroxybutyric Acid?
Description
2-Hydroxybutyric acid (or alpha - hydroxy butyrate) is a hydroxy butyric acid with the hydroxyl group on the carbon adjacent to the carboxyl. It is a chiral compound having two enantiomers, D-2- hydroxybutyric acid and L-2-hydroxybutyric acid.
2-Hydroxy butyrate, the conjugate base of 2-hydroxy butyric acid, is produced in mammalian tissues (principally hepatic) that catabolize L-threonine or synthesize glutathione. Oxidative stress or detoxification demands can dramatically increase the rate of hepatic glutathione synthesis. Under such metabolic stress conditions, supplies of L-cysteine for glutathione synthesis become limiting, so homocysteine is diverted from the transmethylation pathway forming methionine into the transsulfuration pathway forming cystathionine. 2-Hydroxybutyrate is released as a byproduct when cystathionine is cleaved to cysteine that is incorporated into glutathione. Chronic shifts in the rate of glutathione synthesis may be reflected by urinary excretion of 2-hydroxybutyrate.
The Uses of DL-2-Hydroxybutyric Acid
2-Hydroxybutanoic Acid is an analyte used in the diagnoses of colorectal cancer as well as Type II diabetes. It is also used in the purification of the major Vibrio autoinducer and the study of its role in virulence factor production for cholera.
Definition
ChEBI: A hydroxybutyric acid having a single hydroxyl group located at position 2; urinary secretion of 2-hydroxybutyric acid is increased with alcohol ingestion or vigorous physical exercise and is associated with lactic acidosis and ketoacidosis in humans and d abetes in animals.
Properties of DL-2-Hydroxybutyric Acid
Melting point: | 44 °C |
Boiling point: | 260 °C |
Density | 1.1250 |
refractive index | 1.4298 (589.3 nm 20℃) |
storage temp. | Refrigerator |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
pka | pK1:3.65 (30°C) |
form | Solid |
color | White to Off-White Low-Melting |
Merck | 14,4816 |
EPA Substance Registry System | Butanoic acid, 2-hydroxy- (600-15-7) |
Safety information for DL-2-Hydroxybutyric Acid
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DL-2-Hydroxybutyric Acid
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ARRKEM LIFE SCIENCES PRIVATE LIMITED
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