Dithioerythritol

Synonym(s):erythro-1,4-Dimercapto-2,3-butanediol;erythro-2,3-Dihydroxy-1,4-butanedithiol;Cleland’s reagent;Dithioerythitol;DTE

CAS NO.：6892-68-8
Empirical Formula: C4H10O2S2
Molecular Weight: 154.25
MDL number: MFCD00063750
EINECS: 229-998-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-25 16:21:11

What is Dithioerythritol?

Chemical properties

White solid

The Uses of Dithioerythritol

1,4-Dithioerythritol is a Michael reaction acceptor; inducers of enzymes that protect against carcinogenesis: reactivity with sulfhydryl groups.

The Uses of Dithioerythritol

Reagent for the reduction of disulfide group. Prevents oxidation of sulfhydryl-containing proteins during SDS-polyacrylamide gel electrophoresis. Cleavage of disulfide bonds in proteins

The Uses of Dithioerythritol

Reagent for maintaining ?SH groups in the reduced state; quantitatively reduces disulfides.

What are the applications of Application

Dithioerythritol is a useful reagent for maintaining sulfhydryl groups in the reduced state

Definition

ChEBI: The meso-diastereomer of 1,4-dimercaptobutane-2,3-diol; a sulfur-containing sugar derived from the monosaccharide erythrose; and an epimer of dithiothreitol.

Purification Methods

Crystallise DTE from ether/hexane and store it in the dark at 0o. [Beilstein 1 III 2360.]

Properties of Dithioerythritol

Melting point:	82-84 °C(lit.)
Boiling point:	247.65°C (rough estimate)
Density	1.156 (estimate)
refractive index	1.5200 (estimate)
storage temp.	2-8°C
solubility	H₂O: 10 mg/mL, clear, colorless
form	Powder
pka	pK1:9.5 (25°C)
color	White to pale yellow or beige
PH	4.0-6.0 (25℃, 0.1M in H2O)
Water Solubility	Soluble
Sensitive	Air Sensitive
λmax	λ: 260 nm Amax: 0.400 λ: 280 nm Amax: 0.050
BRN	1719756
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	6892-68-8(CAS DataBase Reference)
EPA Substance Registry System	1,4-Dithioerythritol (6892-68-8)

Safety information for Dithioerythritol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment.