Dithioerythritol
Synonym(s):erythro-1,4-Dimercapto-2,3-butanediol;erythro-2,3-Dihydroxy-1,4-butanedithiol;Cleland’s reagent;Dithioerythitol;DTE
- CAS NO.：6892-68-8
- Empirical Formula: C4H10O2S2
- Molecular Weight: 154.25
- MDL number: MFCD00063750
- EINECS: 229-998-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-11-14 17:13:14
What is Dithioerythritol?
Chemical properties
White solid
The Uses of Dithioerythritol
1,4-Dithioerythritol is a Michael reaction acceptor; inducers of enzymes that protect against carcinogenesis: reactivity with sulfhydryl groups.
The Uses of Dithioerythritol
Reagent for the reduction of disulfide group. Prevents oxidation of sulfhydryl-containing proteins during SDS-polyacrylamide gel electrophoresis. Cleavage of disulfide bonds in proteins
The Uses of Dithioerythritol
Reagent for maintaining ?SH groups in the reduced state; quantitatively reduces disulfides.
What are the applications of Application
Dithioerythritol is a useful reagent for maintaining sulfhydryl groups in the reduced state
Definition
ChEBI: The meso-diastereomer of 1,4-dimercaptobutane-2,3-diol; a sulfur-containing sugar derived from the monosaccharide erythrose; and an epimer of dithiothreitol.
Purification Methods
Crystallise DTE from ether/hexane and store it in the dark at 0o. [Beilstein 1 III 2360.]
Properties of Dithioerythritol
| Melting point: | 82-84 °C(lit.) |
| Boiling point: | 247.65°C (rough estimate) |
| Density | 1.156 (estimate) |
| refractive index | 1.5200 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: 10 mg/mL, clear, colorless |
| form | Powder |
| pka | pK1:9.5 (25°C) |
| color | White to pale yellow or beige |
| PH | 4.0-6.0 (25℃, 0.1M in H2O) |
| Water Solubility | Soluble |
| Sensitive | Air Sensitive |
| λmax | λ: 260 nm Amax: 0.400 λ: 280 nm Amax: 0.050 |
| BRN | 1719756 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 6892-68-8(CAS DataBase Reference) |
| EPA Substance Registry System | 1,4-Dithioerythritol (6892-68-8) |
Safety information for Dithioerythritol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H412:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for Dithioerythritol
| InChIKey | VHJLVAABSRFDPM-ZXZARUISSA-N |
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