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HomeProduct name listditazole

ditazole

  • CAS NO.:18471-20-0
  • Empirical Formula: C19H20N2O3
  • Molecular Weight: 324.37
  • MDL number: MFCD00866073
  • EINECS: 242-353-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:35
ditazole Structural

What is ditazole?

Originator

Ageroplas,Serona,Italy,1973

The Uses of ditazole

Ditazole is a weak anti-inflammatory drug and a novel inhibitor of platelet aggregation.

Definition

ChEBI: Ditazole is a member of 1,3-oxazoles.

Manufacturing Process

A solution of 5.1 grams 2-chloro-4,5-diphenyl-oxazole, 6.3 grams diethanolamine and 50 ml absolute ethanol was refluxed for 4 hours. The solvent was stripped at 1 mm and the oily residue was added at 60°C to 100 ml 50% ethanol; by cooling the hydro-alcoholic solution, 4.5 grams of 2-bis(β- hydroxyethyl)amino-4,5-diphenyl-oxazole was obtained (yield, 69.5%). The product crystallized from ethyl ether + petroleum ether, with a MP of 96 to 98°C.

Therapeutic Function

Antiinflammatory

Trade name

Ageroplas (Lepori, Spain; Serono, Italy), Fendazol (Lepori, Portugal).

Mechanism of action

Ditazole is an anti-inflammatory analgesic agent that is of interest primarily for its ability to inhibit platelet aggregation. For example, it normalizes the enhanced platelet activity in cerebrovascular patients suffering transient ischemic attacks.

Synthesis

ditazole is prepared by heating 2- chloro-4,5-diphenyloxazole and diethanolamine in ethanol.
ditazole synthesis

Properties of ditazole

Melting point: 100-101°C
Boiling point: 505.5±60.0 °C(Predicted)
Density  1.237±0.06 g/cm3(Predicted)
storage temp.  Refrigerator
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
pka 14.08±0.10(Predicted)
color  White to Off-White

Safety information for ditazole

Computed Descriptors for ditazole

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