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HomeProduct name listDISIALOGANGLIOSIDE GD1B 2NA

DISIALOGANGLIOSIDE GD1B 2NA

Synonym(s):Ganglioside GD1b, disialo

DISIALOGANGLIOSIDE GD1B 2NA Structural

What is DISIALOGANGLIOSIDE GD1B 2NA?

Description

Ganglioside GD1b is an acidic glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is a component of plasma membranes where it packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events. The concentration of ganglioside GD1b in human brain increases with age, constituting 7.85% of total sialic acid in the brain of 0- to 10-year-old subjects and 20.29% in 11- to 30-year-old subjects. Ganglioside GD1b levels are positively correlated with pilocytic astrocytoma tumor grade, and GD1b has been detected in various other gliomas, including primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas. Ganglioside GD1b mixture contains ganglioside GD1b molecular species with C18:1 and C20:1 fatty acyl chains.

The Uses of DISIALOGANGLIOSIDE GD1B 2NA

Ganglioside GD1b Disodium Salt (Bovine Brain) is a ganglioside, major constituents of neuronal cell membranes and endoplasmic reticulum that have been shown to modulate cell signal transduction.

What are the applications of Application

Ganglioside GD1b disodium salt is a ganglioside

General Description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Biochem/physiol Actions

May act as a bacterial toxin receptor (tetanus, botulinus); high levels found in gliomas and astrocytomas.

Properties of DISIALOGANGLIOSIDE GD1B 2NA

storage temp.  −20°C
solubility  Chloroform:Methanol:DI Water (2:1:0.1): soluble
form  lyophilized powder

Safety information for DISIALOGANGLIOSIDE GD1B 2NA

Computed Descriptors for DISIALOGANGLIOSIDE GD1B 2NA

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