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HomeProduct name listDIPHENOXYLATE HYDROCHLORIDE

DIPHENOXYLATE HYDROCHLORIDE

  • CAS NO.:3810-80-8
  • Empirical Formula: C30H33ClN2O2
  • Molecular Weight: 489.05
  • MDL number: MFCD00058213
  • EINECS: 223-287-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-15 10:43:59
DIPHENOXYLATE HYDROCHLORIDE Structural

What is DIPHENOXYLATE HYDROCHLORIDE?

Chemical properties

White or almost white, crystalline powder.

Originator

Lomotil,Searle,US,1960

The Uses of DIPHENOXYLATE HYDROCHLORIDE

Antiperistaltic; antidiarrheal. Controlled substance (opiate).

Definition

ChEBI: The hydrochloride salt of diphenoxylate.

Manufacturing Process

A mixture of 23 parts of the ethyl ester of 4-phenylisonipecotic acid and 15 parts of 2,2-diphenyl-4-
omobutyronitrile in 19 parts of xylene is heated for 24 hours at 100-120°C and then cooled and filtered to remove the precipitate of the hydro
omide of the ethyl ester of 4-phenylisonipecotic acid. The filtrate is then extracted with dilute hydrochloric acid and the extract is rendered alkaline by addition of concentrated aqueous potassium hydroxide and extracted with ether. This ether extract is treated with gaseous hydrogen chloride. The resulting precipitate is collected on a filter. The hydrochloride of the ethyl ester of 2,2-diphenyl-4-(4'-carboxy-4'-phenyl-1'- piperidino)butyronitrile thus obtained melts at about 220.5-222°C. See meperidine hydrochloride for synthesis of 4-phenyl-isonipecotic acid ethyl ester.

Therapeutic Function

Antidiarrheal

Veterinary Drugs and Treatments

Diphenoxylate is an opiate in combination with atropine in antidiarrheal products used primarily in dogs; it also has antitussive properties. Use in cats is controversial and many clinicians do not recommend its use in this species.

Properties of DIPHENOXYLATE HYDROCHLORIDE

Melting point: 220.5-222°
storage temp.  -20°C
solubility  Very slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
form  Solid
color  White to Off-White

Safety information for DIPHENOXYLATE HYDROCHLORIDE

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H301:Acute toxicity,oral
H317:Sensitisation, Skin
H334:Sensitisation, respiratory
Precautionary Statement Codes P262:Do not get in eyes, on skin, or on clothing.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for DIPHENOXYLATE HYDROCHLORIDE

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