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HomeProduct name listDIISOPROPYLDICHLOROSILANE

DIISOPROPYLDICHLOROSILANE

Synonym(s):Diisopropyldichlorosilane

DIISOPROPYLDICHLOROSILANE Structural

What is DIISOPROPYLDICHLOROSILANE?

Physical properties

bp 50–55°C/5 mmHg.

The Uses of DIISOPROPYLDICHLOROSILANE

Dichlorodiisopropylsilane can be used in nucleoside 3',5'-hydroxy protection; component in Peterson alkenation reaction. The use of silicon groups as protection for hydroxy groups has been widely exploited.3 One potentially useful way to protect a nucleoside is by using a protecting group which spans the 3- and 5-hydroxy groups. One of the useful groups which can be used as a bifunctional protecting group in nucleosides is the diisopropylsilyl group. Reaction of the nucleoside with dichlorodiisopropylsilane and imidazole in DMF gives the protected nucleoside (eq 1).This method has not been widely used; the more common 3',5'-hydroxy-bridging protecting group is a tetraisopropyldisiloxy group. Reactions of DIISOPROPYLDICHLOROSILANE

What are the applications of Application

Dichlorodiisopropylsilane is a protecting group reagent

Preparation

conveniently prepared by the reaction of diisopropylsilane in carbon tetrachloride with palladium(II) chloride at 140°C for 8 h in a steel bomb.Washing the residue with ether and removing the ether by rotary evaporation yields the product which is purified by distillation to yield a clear colorless oil.

Properties of DIISOPROPYLDICHLOROSILANE

Melting point: <0°C
Boiling point: 66 °C27 mm Hg(lit.)
Density  1.026 g/mL at 20 °C(lit.)
refractive index  n20/D 1.444
Flash point: 43°C
solubility  sol most organic solvents.
form  clear liquid
color  Colorless to Light yellow to Light orange
Specific Gravity 1.026
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents
BRN  1736244
CAS DataBase Reference 7751-38-4(CAS DataBase Reference)

Safety information for DIISOPROPYLDICHLOROSILANE

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H226:Flammable liquids
H314:Skin corrosion/irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P240:Ground/bond container and receiving equipment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for DIISOPROPYLDICHLOROSILANE

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