Dihydrochelerythrine
- CAS NO.：6880-91-7
- Empirical Formula: C21H19NO4
- Molecular Weight: 349.38
- MDL number: MFCD02183360
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Dihydrochelerythrine?
Description
Dihydrochelerythrine is a benzophenanthridine alkaloid that has been found in Bocconia arborea and has diverse biological activities. It is active against S. aureus, S. faecalis, and C. albicans (MIC = 1.87 μg/ml for all). Dihydrochelerythrine inhibits secretion of the hepatitis B virus (HBV) antigens HBsAg and HBeAg from HepG2 2.2.15 cells (IC50s = <0.05 μM for both). It is cytotoxic to HCT8, BGC-823, and A2780 cancer cells (IC50s = 1.4, 0.4, and 3.5 μM, respectively).
The Uses of Dihydrochelerythrine
Dihydrochelerythrine is synthesized as a potential G-quadrulpex DNA stabilizing agent. It is used in phamacokinetic study of chelerythrine metabolites in agro-products.
Definition
ChEBI: Dihydrochelerythrine is a benzophenanthridine alkaloid.
Properties of Dihydrochelerythrine
| Melting point: | 164-165 °C |
| Boiling point: | 565.9±50.0 °C(Predicted) |
| Density | 1.291±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO : 50 mg/mL (143.11 mM; Need ultrasonic and warming) |
| form | Powder |
| pka | 2.36±0.20(Predicted) |
| color | White to off-white |
Safety information for Dihydrochelerythrine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. |
Computed Descriptors for Dihydrochelerythrine
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