DIFFRACTIC ACID

CAS NO.：436-32-8
Empirical Formula: C20H22O7
Molecular Weight: 374.38
MDL number: MFCD01684770
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-26 15:15:06

What is DIFFRACTIC ACID?

Description

Diffractaic acid is a lichen metabolite that has been found in P. magellanica and has diverse biological activities. It is cytotoxic to HCT116, HeLa, and MCF-7 cancer cells (IC₅₀s = 42.2, 64.6, and 93.4 μM, respectively). Diffractaic acid inhibits growth of M. tuberculosis (MIC = 41.7 μM). In vivo, diffractaic acid (25-200 mg/kg) reduces neutrophil infiltration, lipid peroxidation, myeloperoxidase (MPx) activity, and the number of gastric lesions as well as reverses decreases in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities induced by indomethacin in rat gastric mucosa. Diffractaic acid also has analgesic activity, reducing acetic acid-induced writhing and increasing the pressure pain threshold in mice.

Definition

ChEBI: 4-[(2,4-dimethoxy-3,6-dimethylphenyl)-oxomethoxy]-2-hydroxy-3,6-dimethylbenzoic acid is a carbonyl compound.

Properties of DIFFRACTIC ACID

Melting point:	189～190℃
Boiling point:	604.9±55.0 °C(Predicted)
Density	1.260±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form	A solid
pka	2.66±0.25(Predicted)
color	White to off-white