Diethyl butylmalonate

CAS NO.：133-08-4
Empirical Formula: C11H20O4
Molecular Weight: 216.27
MDL number: MFCD00009170
EINECS: 205-089-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-01 18:09:03

What is Diethyl butylmalonate?

Chemical properties

CLEAR COLOURLESS LIQUID

The Uses of Diethyl butylmalonate

Diethyl butylmalonate is used as a reagent in the synthesis of 2,5-dihydropyrrole formyl hydroxyamino derivatives as peptide deformylase inhibitors against drug-resistant bacteria.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 1, p. 250, 1941
The Journal of Organic Chemistry, 44, p. 3492, 1979 DOI: 10.1021/jo01334a009

General Description

Diethyl malonate (DEM) undergoes alkylation by ethyliodide, which is used to study the phase transfer catalysis (PTC) technique.

Flammability and Explosibility

Not classified

Properties of Diethyl butylmalonate

Melting point:	238 °C
Boiling point:	235-240 °C (lit.)
Density	0.983 g/mL at 25 °C (lit.)
vapor pressure	1Pa at 20℃
refractive index	n20/D 1.422(lit.)
Flash point:	201 °F
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO : 100 mg/mL (462.38 mM; Need ultrasonic)\|
pka	13.47±0.46(Predicted)
form	clear liquid
color	Colorless to Almost colorless
Specific Gravity	0.975 (20/4℃)
Water Solubility	330mg/L at 20℃
Merck	14,1576
BRN	608785
CAS DataBase Reference	133-08-4(CAS DataBase Reference)
NIST Chemistry Reference	Diethyl butylmalonate(133-08-4)

Safety information for Diethyl butylmalonate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H227:Flammable liquids
Precautionary Statement Codes	P403+P235:Store in a well-ventilated place. Keep cool.