Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listDiethyl allylmalonate

Diethyl allylmalonate

Synonym(s):2-Propenyl-propanedioic acid diethyl ester, Allylmalonic acid diethyl ester;Allylmalonic acid diethyl ester

  • CAS NO.:2049-80-1
  • Empirical Formula: C10H16O4
  • Molecular Weight: 200.23
  • MDL number: MFCD00009155
  • EINECS: 218-072-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-01-29 17:42:43
Diethyl allylmalonate  Structural

What is Diethyl allylmalonate ?

Chemical properties

clear colorless to slightly yellow liquid

The Uses of Diethyl allylmalonate

Diethyl allylmalonate is an important intermediates in syntheses of vitamins B1 and B6, barbiturates, non-steroidal anti-inflammatory agents, other numerous pharmaceuticals, agrochemicals and flavors and fragrances compounds.

Preparation

Diethyl allyl malonate is obtained by reacting diethyl malonate with allyl bromide.
Under nitrogen atmosphere, to a 500 mL three-neck round bottom flask was added diethyl malonate (20 g), anhydrous potassium carbonate (43 g) and anhydrous CH3CN (200 mL). The reaction mixture was stirred at room temperature for 10 minutes, then allyl bromide (23 g) was slowly added to the reaction mixture at room temperature. The reaction mixture was heated to 80°C for 24 hours. The reaction mixture was cooled to room temperature and filtered through a bed of celite. The celite bed was washed with acetonitrile (100 mL) and the combined filtrates were concentrated to give diethyl allylmalonate (24 g) as a colorless liquid.

Synthesis Reference(s)

Chemistry Letters, 17, p. 291, 1988
The Journal of Organic Chemistry, 28, p. 504, 1963 DOI: 10.1021/jo01037a058

Properties of Diethyl allylmalonate

Boiling point: 222-223 °C(lit.)
Density  1.015 g/mL at 25 °C(lit.)
refractive index  n20/D 1.431(lit.)
Flash point: 160 °F
storage temp.  Store below +30°C.
form  Liquid
pka 12.63±0.46(Predicted)
color  Clear colorless to slightly yellow
Water Solubility  Not miscible or difficult to mix with water.
BRN  1709466
CAS DataBase Reference 2049-80-1(CAS DataBase Reference)
NIST Chemistry Reference Propanedioic acid, 2-propenyl-, diethyl ester(2049-80-1)
EPA Substance Registry System Propanedioic acid, 2-propenyl-, diethyl ester (2049-80-1)

Safety information for Diethyl allylmalonate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H227:Flammable liquids
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378:In case of fire: Use … for extinction.
P405:Store locked up.
P403+P235:Store in a well-ventilated place. Keep cool.
P501:Dispose of contents/container to..…

Computed Descriptors for Diethyl allylmalonate

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.