Diethyl allylmalonate
Synonym(s):2-Propenyl-propanedioic acid diethyl ester, Allylmalonic acid diethyl ester;Allylmalonic acid diethyl ester
- CAS NO.:2049-80-1
- Empirical Formula: C10H16O4
- Molecular Weight: 200.23
- MDL number: MFCD00009155
- EINECS: 218-072-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-01-29 17:42:43
What is Diethyl allylmalonate ?
Chemical properties
clear colorless to slightly yellow liquid
The Uses of Diethyl allylmalonate
Diethyl allylmalonate is an important intermediates in syntheses of vitamins B1 and B6, barbiturates, non-steroidal anti-inflammatory agents, other numerous pharmaceuticals, agrochemicals and flavors and fragrances compounds.
Preparation
Diethyl allyl malonate is obtained by reacting diethyl malonate with allyl bromide.
Under nitrogen atmosphere, to a 500 mL three-neck round bottom flask was added diethyl malonate (20 g), anhydrous potassium carbonate (43 g) and anhydrous CH3CN (200 mL). The reaction mixture was stirred at room temperature for 10 minutes, then allyl bromide (23 g) was slowly added to the reaction mixture at room temperature. The reaction mixture was heated to 80°C for 24 hours. The reaction mixture was cooled to room temperature and filtered through a bed of celite. The celite bed was washed with acetonitrile (100 mL) and the combined filtrates were concentrated to give diethyl allylmalonate (24 g) as a colorless liquid.
Synthesis Reference(s)
Chemistry Letters, 17, p. 291, 1988
The Journal of Organic Chemistry, 28, p. 504, 1963 DOI: 10.1021/jo01037a058
Properties of Diethyl allylmalonate
Boiling point: | 222-223 °C(lit.) |
Density | 1.015 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | 160 °F |
storage temp. | Store below +30°C. |
form | Liquid |
pka | 12.63±0.46(Predicted) |
color | Clear colorless to slightly yellow |
Water Solubility | Not miscible or difficult to mix with water. |
BRN | 1709466 |
CAS DataBase Reference | 2049-80-1(CAS DataBase Reference) |
NIST Chemistry Reference | Propanedioic acid, 2-propenyl-, diethyl ester(2049-80-1) |
EPA Substance Registry System | Propanedioic acid, 2-propenyl-, diethyl ester (2049-80-1) |
Safety information for Diethyl allylmalonate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for Diethyl allylmalonate
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ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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