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HomeProduct name listDiethyl 2,6-pyridinedicarboxylate

Diethyl 2,6-pyridinedicarboxylate

Diethyl 2,6-pyridinedicarboxylate Structural

What is Diethyl 2,6-pyridinedicarboxylate?

Chemical properties

Yellow to red crystalline powder

Synthesis

Pyridine-2,6-dicarboxylic acid (10.0g, 59.9mmol) was added into ethanol (120mL), then 3 drops of concentrated sulfuric acid were added. The mixture was heated to reflux for 8 hours. After evaporation of the solvent, the solid residue was washed with saturated Na2CO3 aqueous solution and extracted with chloroform for 3 times. The organic phase was dried with small amount of MgSO4. The solvent was removed to afford 1 as white powder (12.6g, 56.3mmol, yield = 94%). 1 H-NMR (400MHz, CDCl3) |? ppm 8.29 (d, J = 7.80 Hz, 2H), 8.01 (t, J = 7.80, 7.80 Hz, 1H), 4.50 (q, J = 7.12, 7.12, 7.12 Hz, 2H), 1.47 (t, J = 7.13, 7.13 Hz, 3H). 13C-NMR (100 MHz, CDCl3) |? ppm 164.6, 148.6, 138.2,127.8, 62.3,14.2,14.2. ESI MS: m/z = 224.1 [M+H]+ , 246.1 [M+Na]+ .
Synthesis_15658-60-3

Properties of Diethyl 2,6-pyridinedicarboxylate

Melting point: 44°C
Boiling point: 188 °C / 12mmHg
Density  1.165±0.06 g/cm3(Predicted)
storage temp.  Inert atmosphere,Room Temperature
form  powder to crystal
pka -0.20±0.10(Predicted)
color  White to Light yellow to Light orange
CAS DataBase Reference 15658-60-3(CAS DataBase Reference)

Safety information for Diethyl 2,6-pyridinedicarboxylate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Diethyl 2,6-pyridinedicarboxylate

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