Diethyl 2,6-pyridinedicarboxylate
- CAS NO.：15658-60-3
- Empirical Formula: C11H13NO4
- Molecular Weight: 223.23
- MDL number: MFCD00033792
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is Diethyl 2,6-pyridinedicarboxylate?
Chemical properties
Yellow to red crystalline powder
Synthesis
Pyridine-2,6-dicarboxylic acid (10.0g, 59.9mmol) was added into ethanol (120mL),
then 3 drops of concentrated sulfuric acid were added. The mixture was heated to
reflux for 8 hours. After evaporation of the solvent, the solid residue was washed with
saturated Na2CO3 aqueous solution and extracted with chloroform for 3 times. The
organic phase was dried with small amount of MgSO4. The solvent was removed to
afford 1 as white powder (12.6g, 56.3mmol, yield = 94%). 1
H-NMR (400MHz,
CDCl3) |? ppm 8.29 (d, J = 7.80 Hz, 2H), 8.01 (t, J = 7.80, 7.80 Hz, 1H), 4.50 (q, J =
7.12, 7.12, 7.12 Hz, 2H), 1.47 (t, J = 7.13, 7.13 Hz, 3H). 13C-NMR (100 MHz, CDCl3)
|? ppm 164.6, 148.6, 138.2,127.8, 62.3,14.2,14.2. ESI MS: m/z = 224.1 [M+H]+
, 246.1
[M+Na]+
.
Properties of Diethyl 2,6-pyridinedicarboxylate
| Melting point: | 44°C |
| Boiling point: | 188 °C / 12mmHg |
| Density | 1.165±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | -0.20±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| CAS DataBase Reference | 15658-60-3(CAS DataBase Reference) |
Safety information for Diethyl 2,6-pyridinedicarboxylate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Diethyl 2,6-pyridinedicarboxylate
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product: 15658-60-3 diethyl pyridine-2,6-dicarboxylate 98%
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