DIENESTROL
- CAS NO.:13029-44-2
- Empirical Formula: C18H18O2
- Molecular Weight: 266.33
- MDL number: MFCD00050983
- EINECS: 201-519-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:48
What is DIENESTROL?
Absorption
Systemic absorption and mode of action of dienestrol are undetermined.Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
Toxicity
Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females.
Chemical properties
Off-White Solid
The Uses of DIENESTROL
A metabolite of Diethylstilbestrol
The Uses of DIENESTROL
A metabolite of Diethylstilbestrol.
Indications
For use in the treatment of atrophic vaginitis and kraurosis vulvae.
Background
Dienestrol is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist. Estrogens work partly by increasing a normal clear discharge from the vagina and making the vulva and urethra healthy. Using or applying an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness, or soreness of the vulva. Conditions that are treated with vaginal estrogens include a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), and inflammation of the urethra (atrophic urethritis).
What are the applications of Application
E,E-Dienestrol is a metabolite of Diethylstilbestrol
definition
ChEBI: Dienestrol is an olefinic compound that is hexa-2,4-diene substituted by 4-hydroxyphenyl groups at positions 3 and 4 respectively. It has a role as a xenoestrogen. It is a member of phenols and an olefinic compound.
Pharmacokinetics
Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
Metabolism
Hepatic.
Properties of DIENESTROL
Melting point: | 224-226°C |
Boiling point: | 349.54°C (rough estimate) |
Density | 1.1305 (rough estimate) |
refractive index | 1.4800 (estimate) |
storage temp. | Amber Vial, -20°C Freezer, Under Inert Atmosphere |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 10.18±0.15(Predicted) |
color | Pale Beige |
Stability: | Light sensitive |
Safety information for DIENESTROL
Computed Descriptors for DIENESTROL
New Products
3-Pyridineacrylic acid 3-Bromo-4-fluorophenol N-Boc-Ethylenediamine cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate 4-Aminotetrahydropyran hydrochloride 4,5-Dibromopyridazin-3-one N-Benzyl-3-hydroxypiperidine 2-Methyl-4-nitrobenzoic acid 2-(4-bromophenyl)-2-methylpropanoic acid 4-Acetyl-2-methylbenzoicacid Acetyl-meldrum's acid Ethyl-4-Pyrazole carboxylate 2,6-Pyridinedimethanol 5,7-Dichloro-3H-Imidazo[4,5-B]Pyridine 5-Bromo-2-Methoxy-4-Methyl-3-Nitropyridine 2-Fluoro-5-Iodopyridine 2-Fluoro-5-Methylpyridine 2-Chloro-3-Bromo-5-Amiopyridine METHYL-4-(BUTYRYLAMINO)3-METHYL-5-NITROBENZOATE TRANS-CYCLOBUTANE-1,2- DICARBOXYLIC ACID 5-Nitro indazole R-(-)-5-(2-AMINO-PROPYL)-2-METHOXY-BENZENESULFONAMIDE 1,3-cyclohexanedione 4-AminophenaethylalcholRelated products of tetrahydrofuran
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