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HomeProduct name listdibenzo[b,d]furan-3-ylboronic acid

dibenzo[b,d]furan-3-ylboronic acid

  • CAS NO.:395087-89-5
  • Empirical Formula: C12H9BO3
  • Molecular Weight: 212.01
  • MDL number: MFCD26516274
  • Update Date: 2022-12-30 16:20:48
dibenzo[b,d]furan-3-ylboronic acid Structural

What is dibenzo[b,d]furan-3-ylboronic acid?

The Uses of dibenzo[b,d]furan-3-ylboronic acid

Dibenzo[b,d]furan-3-ylboronic acid can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical and pharmaceutical production processes.

Synthesis

In a 300 ml three-necked flask, 7.2 g of 4-bromodibenzofuran was dissolved in ?78° C. anhydrous tetrahydrofuran (THF) under an argon atmosphere. Then, 20 ml of an n-butyl lithium-n-hexane solution (1.6 M, 1.1 eq) was added and stirred for 1 hour. 4.23 ml (1.3 eq) of trimethoxyborane (B(OMe)3) was added and stirred for 2 hours, and the temperature of the reaction system was increased to room temperature. 200 ml of 1 N hydrochloric acid was added into the reactant and stirred for 3 hours. An organic layer was separated, and solvents were distilled off. In the crude product thus obtained, hexane was added. Precipitated product was filtered to obtain 4.94 g of dibenzofuran-4-boronic acid as a white solid (yield 80percent). The product was measured by FAB-MS, and dibenzofuran-4-boronic acid having a molecular weight of 212 was detected.

Properties of dibenzo[b,d]furan-3-ylboronic acid

Boiling point: 438.5±37.0 °C(Predicted)
Density  1.34±0.1 g/cm3(Predicted)
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
pka 8.20±0.30(Predicted)

Safety information for dibenzo[b,d]furan-3-ylboronic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for dibenzo[b,d]furan-3-ylboronic acid

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