1-Dibenzofuranylboronic Acid
- CAS NO.:162607-19-4
- Empirical Formula: C12H9BO3
- Molecular Weight: 212.01
- MDL number: MFCD01318978
- EINECS: 829-640-6
- Update Date: 2024-09-23 17:56:10
What is 1-Dibenzofuranylboronic Acid?
The Uses of 1-Dibenzofuranylboronic Acid
Dibenzo[b,d]furan-1-ylboronic acid can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and chemical production processes.
Synthesis
180 g (728 mmol) of 1-bromodibenzofuran aredissolved in 1500 ml of dry THF and cooled to -78?? C. 305 ml (764 mmol/2.5 M in hexane) of n-butyllithium are added at this temperature over the course of about 5 min., and the mixture is subsequently stirred at -78?? C. for a further 2.5 h. 151 g (1456 mmol) of trimethyl borate are added as rapidly as possible at this temperature, and the reaction mixture is allowed to come slowly to room temperature (about 18 h). The reaction solution is washed with water, and the precipitated solid and the organic phase are dried azeo- tropically with toluene. The crude product is washed by stirring with toluene/methylene chloride at about 40?? C. and filtered off with suction. Yield: 146 g (690 mmol), 95% of theory.
Properties of 1-Dibenzofuranylboronic Acid
Boiling point: | 438.5±37.0 °C(Predicted) |
Density | 1.34±0.1 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
form | powder to crystal |
pka | 8.20±0.30(Predicted) |
color | White to Almost white |
Safety information for 1-Dibenzofuranylboronic Acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Dibenzofuranylboronic Acid
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