DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE

Synonym(s):N,N-Bis(1-methylethyl)phosphoramidous acid di-2-propenyl ester;Diallyloxy(diisopropylamino)phosphine

CAS NO.：126429-21-8
Empirical Formula: C12H24NO2P
Molecular Weight: 245.3
MDL number: MFCD00216647
SAFETY DATA SHEET (SDS)
Update Date: 2022-11-11 11:01:00

DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE Structural

What is DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE?

The Uses of DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE

Diallyl N,N-diisopropylphosphoramidite is a reagent used in the synthesis of Leustroducsin B that exhibits large variety of biological activities. It also acts as a reagent in the synthesis of water-soluble prodrugs of triazole CS-758 with antifungal activities.

The Uses of DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE

Precursor involved in the synthesis of pharmacologically active molecules including:• ;Selective orally active S1P1 agonists1• ;Water-soluble prodrugs of triazole CS-758 with antifungal activity2• ;Fostriecin analogs as antitumor agents3Reactant involved in: • ;Phosphitylation of alcohols4• ;Deallylation for the synthesis of nucleoside phosphoramidite5• ;Posphitylation and stereoselective Pudovik rearrangement6

The Uses of DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE

Precursor involved in the synthesis of pharmacologically active molecules including:

Selective orally active S1P1 agonists
Water-soluble prodrugs of triazole CS-758 with antifungal activity
Fostriecin analogs as antitumor agents

Reactant involved in:

Phosphitylation of alcohols
Deallylation for the synthesis of nucleoside phosphoramidite
Posphitylation and stereoselective Pudovik rearrangement

Properties of DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE

Boiling point:	130 °C(lit.)
Density	0.928 g/mL at 25 °C(lit.)
refractive index	n20/D 1.456(lit.)
Flash point:	90 °F
storage temp.	2-8°C
pka	4.96±0.70(Predicted)
BRN	4383514

Safety information for DIALLYL N,N-DIISOPROPYLPHOSPHORAMIDITE

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.