Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listDi-tert-butyl Chloromethyl Phosphate

Di-tert-butyl Chloromethyl Phosphate

Di-tert-butyl Chloromethyl Phosphate Structural

What is Di-tert-butyl Chloromethyl Phosphate?

Description

Di-tert-butyl (chloromethyl) phosphate has become one of the most common reagents to prepare phosphon-oxymethyl pro-drugs, generally by direct alkylation of hydroxyl or amino groups. Its synthesis was first reported in 1999 via a reaction of di-tert-butyl tetramethylammonium phosphate with chloroiodomethane. This approach required the use of the corresponding tetramethylammonium phosphate and a vast excess (>11 equiv) of chloroiodomethane to minimize the formation of tetra-tert-butyl methylene bisphosphate[1].

The Uses of Di-tert-butyl Chloromethyl Phosphate

Used as an intermediate for laboratory research.

Synthesis

Di-tert-butyl (chloromethyl) phosphate, a key compound in the formation of many phosphon-oxymethyl pro-drugs,  is prepared by reacting chloromethyl chlorosulfate (CMCS) with di-tert-butyl potassium phosphate (DTBPP) .

References

[1] Bin Zheng*. “Development of Efficient Processes for the Preparation of Di-tert-butyl Potassium Phosphate and Di-tert-butyl (Chloromethyl) Phosphate.” Organic Process Research & Development 18 5 (2014): 636–642.

Properties of Di-tert-butyl Chloromethyl Phosphate

Boiling point: 272.9±23.0 °C(Predicted)
Density  1.115±0.06 g/cm3(Predicted)
storage temp.  Inert atmosphere,2-8°C
solubility  Benzene (Slightly), Methanol (Slightly)
form  clear liquid
color  Colorless to Light yellow
Stability: Moisture Sensitive
InChI InChI=1S/C9H20ClO4P/c1-8(2,3)13-15(11,12-7-10)14-9(4,5)6/h7H2,1-6H3
CAS DataBase Reference 229625-50-7

Safety information for Di-tert-butyl Chloromethyl Phosphate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Di-tert-butyl Chloromethyl Phosphate

InChIKey LNJAJHJFSKUCIR-UHFFFAOYSA-N
SMILES P(OC(C)(C)C)(OC(C)(C)C)(OCCl)=O

Related products of tetrahydrofuran

You may like

  • 229625-50-7 Di-Tertbutyl Chloromethyl Phosphate 98%
    229625-50-7 Di-Tertbutyl Chloromethyl Phosphate 98%
    229625-50-7
    View Details
  • 229625-50-7 98%
    229625-50-7 98%
    229625-50-7
    View Details
  • Di-tert-butyl Chloromethyl Phosphate 229625-50-7 98%
    Di-tert-butyl Chloromethyl Phosphate 229625-50-7 98%
    229625-50-7
    View Details
  • 229625-50-7 98%
    229625-50-7 98%
    229625-50-7
    View Details
  • 229625-50-7 Di-tert-butyl chloromethyl phosphate 98%
    229625-50-7 Di-tert-butyl chloromethyl phosphate 98%
    229625-50-7
    View Details
  • Di-tert-butyl chloromethyl phosphate 98%
    Di-tert-butyl chloromethyl phosphate 98%
    View Details
  • Di-tert-butyl chloromethyl phosphate 95% CAS 229625-50-7
    Di-tert-butyl chloromethyl phosphate 95% CAS 229625-50-7
    229625-50-7
    View Details
  • Di-tert-butyl chloromethyl phosphate, 97% CAS 229625-50-7
    Di-tert-butyl chloromethyl phosphate, 97% CAS 229625-50-7
    229625-50-7
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.