Dextran Sulfate Sodium Salt

Chemical properties

White to off-white powder

The Uses of Dextran Sulfate Sodium Salt

Dextran sulfate sodium salt Leuconostoc spp has been used:

• as a standard to perform polyacrylamide-gel electrophoresis for carbohydrates (C-PAGE)(59) and agarose gel electrophoresis(60)
• for RNA sequential probing of targets (SPOTs) imaging(61)
• as a component of 1% injection buffer(62)

The Uses of Dextran Sulfate Sodium Salt

Clinical reagent (HDL cholesterol determination).

The Uses of Dextran Sulfate Sodium Salt

Clinical studies indicate a possible capacity of dextran sulfate to reduce edema. It is cited as a binder and skin conditioner.

What are the applications of Application

Dextran Sulfate, Sodium Salt MW ~500,000 is a complex branched glucan used to apply osmotic pressure to biological molecules.

Definition

ChEBI: Benzocaine is a benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina. It has a role as a topical anaesthetic, an antipruritic drug, an allergen and a sensitiser. It is a benzoate ester and a substituted aniline.

General Description

Dextran sulfate is a sulfated polysaccharide, which is negatively charged. It is produced by the esterification of dextran with chlorosulphonic acid. Dextran is used to treat hemorrhage, burns, surgery and trauma. It improves blood flow and prevents erythrocyte aggregation. Dextran lowers the risk of thrombosis and postoperative pulmonary emboli. It is a ribonuclease inhibitor. Dextran sulfate exhibits antiviral, anticoagulant and adjuvant properties.

Biochem/physiol Actions

Dextran is a mixture of glucose polymers of varying size and geometry.Dextran in the form of dextran sulphate sodium acts as an anticoagulant. Dextran interferes with blood clot formation by acting on blood coagulation factors and the function of platelets. It prolongs the time required for formation of the clot and decreases the maximum clot strength. The disturbance of homeostasis by dextran may cause increased bleeding, colitis and kidney failure.