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HomeProduct name listDEBRISOQUIN SULFATE

DEBRISOQUIN SULFATE

Synonym(s):3,4-Dihydro-2(1H)-isoquinolinecarboximidamide;Debrisoquin sulfate;Ro 5-33071

  • CAS NO.:581-88-4
  • Empirical Formula: C20H28N6O4S
  • Molecular Weight: 448.54
  • MDL number: MFCD00153791
  • EINECS: 209-472-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
DEBRISOQUIN SULFATE Structural

What is DEBRISOQUIN SULFATE?

Chemical properties

Crystalline Solid

Originator

Declinax,Roche,UK,1967

The Uses of DEBRISOQUIN SULFATE

Antihypertensive

The Uses of DEBRISOQUIN SULFATE

Antihypertensive.

What are the applications of Application

Debrisoquin sulfate is an antihypertensive that is an useful indicator for cytochrome P-450 polymorphism

Manufacturing Process

27 g of 1,2,3,4-tetrahydroisoquinoline was added at room temperature to a solution of 28 g of 2-methyl-2-isothiourea sulfate in 80 ml of water. The resulting mixture was kept at room temperature with occasional shaking. After a short period of time, methylmercaptan began to escape, and the mixture warmed up slightly. After then standing for 24 hours, crystals formed. They were filtered off and rinsed with ice cold water. Recrystallization from approximately 100 ml of water yielded 1,2,3,4-tetrahydroisoquinoline-2- carboxamidine sulfate melting at 278°C to 280°C (uncorr.).
Another batch prepared in the same manner melted at 284°C to 285°C due to a minute difference in moisture content.
Both batches prepared above analyzed correctly for (C10H13N3)2·H2SO4.

brand name

Declinax (HoffmannLaRoche).

Therapeutic Function

Antihypertensive

Biochem/physiol Actions

Debrisoquine is an anti-hypertensive agent. It is metabolized by cytochrome P4502D6.

Properties of DEBRISOQUIN SULFATE

Melting point: 278-280°, 284-285° or 266-268° (H2O)
storage temp.  room temp
solubility  H2O: 20 mg/mL with heat
form  Solid
color  Pale Yellow

Safety information for DEBRISOQUIN SULFATE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for DEBRISOQUIN SULFATE

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