DEBRISOQUIN SULFATE
Synonym(s):3,4-Dihydro-2(1H)-isoquinolinecarboximidamide;Debrisoquin sulfate;Ro 5-33071
- CAS NO.:581-88-4
- Empirical Formula: C20H28N6O4S
- Molecular Weight: 448.54
- MDL number: MFCD00153791
- EINECS: 209-472-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:01
What is DEBRISOQUIN SULFATE?
Chemical properties
Crystalline Solid
Originator
Declinax,Roche,UK,1967
The Uses of DEBRISOQUIN SULFATE
Antihypertensive
The Uses of DEBRISOQUIN SULFATE
Antihypertensive.
What are the applications of Application
Debrisoquin sulfate is an antihypertensive that is an useful indicator for cytochrome P-450 polymorphism
Manufacturing Process
27 g of 1,2,3,4-tetrahydroisoquinoline was added at room temperature to a
solution of 28 g of 2-methyl-2-isothiourea sulfate in 80 ml of water. The
resulting mixture was kept at room temperature with occasional shaking. After
a short period of time, methylmercaptan began to escape, and the mixture
warmed up slightly. After then standing for 24 hours, crystals formed. They
were filtered off and rinsed with ice cold water. Recrystallization from
approximately 100 ml of water yielded 1,2,3,4-tetrahydroisoquinoline-2-
carboxamidine sulfate melting at 278°C to 280°C (uncorr.).
Another batch prepared in the same manner melted at 284°C to 285°C due to
a minute difference in moisture content.
Both batches prepared above analyzed correctly for (C10H13N3)2·H2SO4.
brand name
Declinax (HoffmannLaRoche).
Therapeutic Function
Antihypertensive
Biochem/physiol Actions
Debrisoquine is an anti-hypertensive agent. It is metabolized by cytochrome P4502D6.
Properties of DEBRISOQUIN SULFATE
Melting point: | 278-280°, 284-285° or 266-268° (H2O) |
storage temp. | room temp |
solubility | H2O: 20 mg/mL with heat |
form | Solid |
color | Pale Yellow |
Safety information for DEBRISOQUIN SULFATE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for DEBRISOQUIN SULFATE
New Products
Tubulysin E Tubulysin C 2,2-diethoxyethanethioamide Tubulysin M Potassium HMDS (1.0 M in THF) 3-N-BOC-(S)-AMINO BUTYRONITRILE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2,2-Difluoropropanol 2,2-Difluoropropylamine hydrochloride 2H-Pyran, 4-ethynyltetrahydro- Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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