DCB

CAS NO.：6971-97-7
Empirical Formula: C14H10Cl2N2
Molecular Weight: 277.15
MDL number: MFCD00556081
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-09 19:38:33

What is DCB?

The Uses of DCB

DCB is an allosteric ligand for mGluR-5 (1). Regulates glutamate concentration however may induce neuronal damage through cerebral ischemia (2).

What are the applications of Application

DCB is an allosteric ligand for mGluR-5

Biological Activity

Allosteric ligand for the metabotropic glutamate receptor mGlu 5 ; displays neutral modulation. Does not affect agonist-stimulated mGlu 5 responses, but blocks regulation of the receptor by other allosteric modulators such as DFB ([(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde ) and DMeOB ([(3-Methoxyphenyl)methylene]hydrazone-3-methoxybenzaldehyde ).

Properties of DCB

Melting point:	40 °C
Boiling point:	387.8±42.0 °C(Predicted)
Density	1.21±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ~6.8 mg/mL
form	solid
pka	5.84±0.50(Predicted)
color	yellow

Safety information for DCB

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.