DBCO-PEG4-SE
Synonym(s):DBCO-PEG4-NHS ester;DBCO-PEG4-SE;DBCO-PEG4-succinimidyl ester
- CAS NO.:1427004-19-0
- Empirical Formula: C34H39N3O10
- Molecular Weight: 649.69
- MDL number: MFCD26793797
- Update Date: 2024-11-19 23:02:33
What is DBCO-PEG4-SE?
Description
DBCO-PEG4-NHS Ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions.
The Uses of DBCO-PEG4-SE
Succinimidyl ester (NHS, amine reactive) functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free click chemistry cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
Applications Include:
- Protein-peptide conjugates
- Antibody-enzyme or antibody-drug conjugates
- Protein or peptide-oligonucleotide conjugates
- Surface modification
Properties of DBCO-PEG4-SE
Density | 1.33±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO, DCM, DMF |
pka | 15.14±0.46(Predicted) |
color | Colourless to yellow |
Safety information for DBCO-PEG4-SE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DBCO-PEG4-SE
InChIKey | RRCXYKNJTKJNTD-UHFFFAOYSA-N |
SMILES | C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCNC(=O)CCC(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)=O |
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