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HomeProduct name listDBCO-PEG4-SE

DBCO-PEG4-SE

Synonym(s):DBCO-PEG4-NHS ester;DBCO-PEG4-SE;DBCO-PEG4-succinimidyl ester

  • CAS NO.:1427004-19-0
  • Empirical Formula: C34H39N3O10
  • Molecular Weight: 649.69
  • MDL number: MFCD26793797
  • Update Date: 2024-10-31 18:15:48
DBCO-PEG4-SE Structural

What is DBCO-PEG4-SE?

Description

DBCO-PEG4-NHS Ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions.

The Uses of DBCO-PEG4-SE

Succinimidyl ester (NHS, amine reactive) functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free click chemistry cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Applications Include:

  • Protein-peptide conjugates
  • Antibody-enzyme or antibody-drug conjugates
  • Protein or peptide-oligonucleotide conjugates
  • Surface modification

Properties of DBCO-PEG4-SE

Density  1.33±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  Soluble in DMSO, DCM, DMF
pka 15.14±0.46(Predicted)
color  Colourless to yellow

Safety information for DBCO-PEG4-SE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for DBCO-PEG4-SE

InChIKey RRCXYKNJTKJNTD-UHFFFAOYSA-N
SMILES C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCNC(=O)CCC(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)=O

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