DBCO-NHS Ester
- CAS NO.:1353016-71-3
- Empirical Formula: C23H18N2O5
- Molecular Weight: 402.4
- MDL number: MFCD24386367
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is DBCO-NHS Ester?
Description
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.
The Uses of DBCO-NHS Ester
DBCO-NHS Ester is a derivative of DBCO (Dibenzylcyclooctyne), used in Cu-free click chemistry. It useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. Used in DNA-Assisted protein analysis such as proximity ligation and extention assays. Intracellular Imaging.
The Uses of DBCO-NHS Ester
DBCO NHS ester contains an NHS carbonate group and a DBCO group. The spacer contains a photocleavable nitrobenzyloxyl group, which can be efficiently cleaved under UV to release the conjugated molecules. DBCO on the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.
What are the applications of Application
Dibenzocyclooctyne-N-hydroxysuccinimidyl ester is an amine reactive crosslinker for incorporation of the cyclooctyne moiety
Properties of DBCO-NHS Ester
Boiling point: | 670.2±65.0 °C(Predicted) |
Density | 1.43±0.1 g/cm3(Predicted) |
solubility | Soluble in DMSO, DCM, DMF |
pka | -0.23±0.20(Predicted) |
form | Solid |
color | White to Off-White |
Stability: | Moisture Sensitive |
Safety information for DBCO-NHS Ester
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DBCO-NHS Ester
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION INOSITOL PANTOPRAZOLE SODIUM SESQUIHYDRATE Metformin FLUCLOXACILLIN SODIUM STERILE NIMESULIDE BP ZONISAMIDE 1,1-Dimethylethyl 4-(2-azidoacetyl)-1-piperidinecarboxylate 2-Bromo-1-(bromomethyl)-3-iodo-5-nitrobenzene 1,2-Dibromo-3-(bromomethyl)-5-nitrobenzene 2-Cyano-5-pyrimidineacetonitrile 7-Fluoro-4-cinnolinamine 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzeneRelated products of tetrahydrofuran
You may like
-
Dbco-nhs ester 95% CAS 1353016-71-3View Details
1353016-71-3 -
1823754-06-8 98%View Details
1823754-06-8 -
1935373-20-8 3-(Bromomethyl)-6-fluoro-1,2-benzenediamine 98%View Details
1935373-20-8 -
2-Chloro-5-(iodomethyl)pyrimidine 2268818-88-6 98%View Details
2268818-88-6 -
2092793-98-9 98%View Details
2092793-98-9 -
1360944-55-3 7-Methoxy-1H-indol-5-amine 98%View Details
1360944-55-3 -
2090480-14-9 98%View Details
2090480-14-9 -
1-Methyl 2-bromo-5-[(1-carboxy-1-methylethyl)amino]benzoate 1651844-56-2 98%View Details
1651844-56-2