DBCO-NHS Ester
- CAS NO.:1353016-71-3
- Empirical Formula: C23H18N2O5
- Molecular Weight: 402.4
- MDL number: MFCD24386367
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is DBCO-NHS Ester?
Description
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.
The Uses of DBCO-NHS Ester
DBCO-NHS Ester is a derivative of DBCO (Dibenzylcyclooctyne), used in Cu-free click chemistry. It useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. Used in DNA-Assisted protein analysis such as proximity ligation and extention assays. Intracellular Imaging.
The Uses of DBCO-NHS Ester
DBCO NHS ester contains an NHS carbonate group and a DBCO group. The spacer contains a photocleavable nitrobenzyloxyl group, which can be efficiently cleaved under UV to release the conjugated molecules. DBCO on the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.
What are the applications of Application
Dibenzocyclooctyne-N-hydroxysuccinimidyl ester is an amine reactive crosslinker for incorporation of the cyclooctyne moiety
Properties of DBCO-NHS Ester
Boiling point: | 670.2±65.0 °C(Predicted) |
Density | 1.43±0.1 g/cm3(Predicted) |
solubility | Soluble in DMSO, DCM, DMF |
pka | -0.23±0.20(Predicted) |
form | Solid |
color | White to Off-White |
Stability: | Moisture Sensitive |
Safety information for DBCO-NHS Ester
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DBCO-NHS Ester
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