DBCO-PEG4-maleimide
Synonym(s):DBCO-PEG4-maleimide
- CAS NO.:1480516-75-3
- Empirical Formula: C36H42N4O9
- Molecular Weight: 674.74
- MDL number: MFCD22572659
- Update Date: 2024-10-28 23:16:16
What is DBCO-PEG4-maleimide?
Description
DBCO-PEG4-Maleimide is PEG linker containing a maleimide group and a DBCO moiety. The hydrophilic PEG spacer arm improves solubility in aqueous buffers. Maleimide group specifically and efficiently reacts with thiols to form stable thioether bonds. The low mass weight will add minimal spacer to modified molecules and will enable simple and efficient incorporation of DBCO moiety onto cysteine-containing peptides or other thiol-containing biomolecules. DBCO is commonly used for copper-free Click Chemistry reactions.
The Uses of DBCO-PEG4-maleimide
Maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. The PEG lipophilic spacer helps to reduce aggregation and precipitation problems when labeling biomolecules.
Applications Include:
- Protein-peptide conjugates
- Antibody-enzyme or antibody-drug conjugates
- Protein or peptide-oligonucleotide conjugates
- Surface modification
What are the applications of Application
DBCO-PEG4-maleimide is a sulfhydryl reactive crosslinker for incorporation of the cyclooctyne moiety
Properties of DBCO-PEG4-maleimide
Boiling point: | 965.2±65.0 °C(Predicted) |
Density | 1.31±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO, DCM, DMF |
pka | 15.01±0.46(Predicted) |
form | Viscous liquid |
color | Colorless to light yellow |
Safety information for DBCO-PEG4-maleimide
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
Computed Descriptors for DBCO-PEG4-maleimide
InChIKey | VVFZXPZWVJMYPX-UHFFFAOYSA-N |
SMILES | N1(CCC(NCCOCCOCCOCCOCCC(=O)NCCC(N2CC3=CC=CC=C3C#CC3=CC=CC=C23)=O)=O)C(=O)C=CC1=O |
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