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HomeProduct name listDBCO-PEG4-maleimide

DBCO-PEG4-maleimide

Synonym(s):DBCO-PEG4-maleimide

  • CAS NO.:1480516-75-3
  • Empirical Formula: C36H42N4O9
  • Molecular Weight: 674.74
  • MDL number: MFCD22572659
  • Update Date: 2024-10-28 23:16:16
DBCO-PEG4-maleimide Structural

What is DBCO-PEG4-maleimide?

Description

DBCO-PEG4-Maleimide is PEG linker containing a maleimide group and a DBCO moiety. The hydrophilic PEG spacer arm improves solubility in aqueous buffers. Maleimide group specifically and efficiently reacts with thiols to form stable thioether bonds. The low mass weight will add minimal spacer to modified molecules and will enable simple and efficient incorporation of DBCO moiety onto cysteine-containing peptides or other thiol-containing biomolecules. DBCO is commonly used for copper-free Click Chemistry reactions.

The Uses of DBCO-PEG4-maleimide

Maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. The PEG lipophilic spacer helps to reduce aggregation and precipitation problems when labeling biomolecules.
Applications Include:

  • Protein-peptide conjugates
  • Antibody-enzyme or antibody-drug conjugates
  • Protein or peptide-oligonucleotide conjugates
  • Surface modification

What are the applications of Application

DBCO-PEG4-maleimide is a sulfhydryl reactive crosslinker for incorporation of the cyclooctyne moiety

Properties of DBCO-PEG4-maleimide

Boiling point: 965.2±65.0 °C(Predicted)
Density  1.31±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  Soluble in DMSO, DCM, DMF
pka 15.01±0.46(Predicted)
form  Viscous liquid
color  Colorless to light yellow

Safety information for DBCO-PEG4-maleimide

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P312:Call a POISON CENTER or doctor/physician if you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P233:Store in a well-ventilated place. Keep container tightly closed.

Computed Descriptors for DBCO-PEG4-maleimide

InChIKey VVFZXPZWVJMYPX-UHFFFAOYSA-N
SMILES N1(CCC(NCCOCCOCCOCCOCCC(=O)NCCC(N2CC3=CC=CC=C3C#CC3=CC=CC=C23)=O)=O)C(=O)C=CC1=O

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