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HomeProduct name listDBCO-PEG4-biotin

DBCO-PEG4-biotin

Synonym(s):DBCO-PEG4-biotin

  • CAS NO.:1255942-07-4
  • Empirical Formula: C39H51N5O8S
  • Molecular Weight: 749.92
  • MDL number: MFCD22572661
  • Update Date: 2024-10-30 18:52:02
DBCO-PEG4-biotin Structural

What is DBCO-PEG4-biotin?

Description

DBCO-PEG4-biotin is a click chemistry biotinylation that can enable copper-free click chemistry with azide molecules to form a stable triazole linkage. PEG4 spacer increases aqueou solubility of the molecules conjugated to the biotin compound.

The Uses of DBCO-PEG4-biotin

DBCO-PEG4-Biotin is used in preparation of array-based cyclic peptide libraries.

The Uses of DBCO-PEG4-biotin

activity-based protein profiling detection of newly synthesized proteins immobilization of azide-labeled biomolecules.

General Description

This azadibenzocyclooctyne-biotin derivative is a versatile biotinylation reagent for labeling azide containing molecules or compounds. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions.This dibenzocyclooctyne will react with azide-functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. Subsequent labeled molecules can be purified using streptavidin or avidin affinity reagents. The PEG spacer makes the overall compound more hydrophilic and allows for greater distance between the reaction site with the azide and the biotin detecting group.

storage

Store at -20°C

Properties of DBCO-PEG4-biotin

Boiling point: 1062.4±65.0 °C(Predicted)
Density  1.30±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  Soluble in Water, DMSO, DMF, DCM
pka 13.90±0.40(Predicted)
form  Solid
color  Off-white to yellow

Safety information for DBCO-PEG4-biotin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for DBCO-PEG4-biotin

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