Dansyl chloride
Synonym(s):5-(Dimethylamino)naphthalene-1-sulfonyl chloride;DNSCl;5-(Dimethylamino)-napthalene-1-sulfonyl Chloride;DNS Chloride;1-Dimethylaminonaphthalene-5-sulfonyl chloride
- CAS NO.:605-65-2
- Empirical Formula: C12H12ClNO2S
- Molecular Weight: 269.75
- MDL number: MFCD00003985
- EINECS: 210-092-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:44
What is Dansyl chloride?
Chemical properties
yellow to orange-yellow crystalline powder
The Uses of Dansyl chloride
Dansyl chloride is a fluorogenic reagent used for protein, N-terminal amino acid and peptide detection by reverse phase high performance liquid chromatography (HPLC). It is also used to determine the degree of labeling in chymotrypsin and ovalbumin. It acts as a precursor for the synthesis of other derivatives like dansyl amide.
The Uses of Dansyl chloride
Reagent for fluorescent labelling of amines, amino acids and proteins.
The Uses of Dansyl chloride
A fluorogenic reagent for N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.
The Uses of Dansyl chloride
In fluorescent labelling, column chromatography, HPLC.
Definition
ChEBI: Dansyl chloride is an aminonaphthalene and a sulfonic acid derivative.
General Description
Dansyl chloride is a fluorogenic reagent which is typically employed for the derivatization of amino acids.
Biochem/physiol Actions
Dansyl chloride is a sulfonyl chloride compound. It is used to end tag amino groups of peptides and proteins. Dansyl chloride is used for derivatization of free amino acids and amines in neural samples and biological fluids. It is used to study fluorescent conjugates of albumin, protein conformational changes studies and active site characterization.
Safety Profile
Poison by intravenous route, When heated to decomposition it emits very toxic fumes of Cland NOx
Properties of Dansyl chloride
Melting point: | 72-74 °C(lit.) |
Boiling point: | 371.3±22.0 °C(Predicted) |
Density | 1.1702 (rough estimate) |
refractive index | 1.5630 (estimate) |
storage temp. | 2-8°C |
solubility | acetone: 50 mg/mL |
form | powder and chunks |
pka | 2.38±0.40(Predicted) |
color | yellow to orange |
Water Solubility | Soluble in dimethyl fluoride, acetone, chloroform, pyridine, benzene and dioxane. Insoluble in water. |
Sensitive | Moisture Sensitive |
Merck | 14,2814 |
BRN | 2217205 |
Stability: | Hygroscopic, Moisture Sensitive |
CAS DataBase Reference | 605-65-2(CAS DataBase Reference) |
EPA Substance Registry System | 1-Naphthalenesulfonyl chloride, 5-(dimethylamino)- (605-65-2) |
Safety information for Dansyl chloride
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H290:Corrosive to Metals H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for Dansyl chloride
InChIKey | XPDXVDYUQZHFPV-UHFFFAOYSA-N |
Abamectin manufacturer
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED
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