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HomeProduct name listDansyl chloride

Dansyl chloride

Synonym(s):5-(Dimethylamino)naphthalene-1-sulfonyl chloride;DNSCl;5-(Dimethylamino)-napthalene-1-sulfonyl Chloride;DNS Chloride;1-Dimethylaminonaphthalene-5-sulfonyl chloride

  • CAS NO.:605-65-2
  • Empirical Formula: C12H12ClNO2S
  • Molecular Weight: 269.75
  • MDL number: MFCD00003985
  • EINECS: 210-092-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-15 10:43:44
Dansyl chloride Structural

What is Dansyl chloride?

Chemical properties

yellow to orange-yellow crystalline powder

The Uses of Dansyl chloride

Dansyl chloride is a fluorogenic reagent used for protein, N-terminal amino acid and peptide detection by reverse phase high performance liquid chromatography (HPLC). It is also used to determine the degree of labeling in chymotrypsin and ovalbumin. It acts as a precursor for the synthesis of other derivatives like dansyl amide.

The Uses of Dansyl chloride

Reagent for fluorescent labelling of amines, amino acids and proteins.

The Uses of Dansyl chloride

A fluorogenic reagent for N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.

The Uses of Dansyl chloride

In fluorescent labelling, column chromatography, HPLC.

Definition

ChEBI: Dansyl chloride is an aminonaphthalene and a sulfonic acid derivative.

General Description

Dansyl chloride is a fluorogenic reagent which is typically employed for the derivatization of amino acids.

Biochem/physiol Actions

Dansyl chloride is a sulfonyl chloride compound. It is used to end tag amino groups of peptides and proteins. Dansyl chloride is used for derivatization of free amino acids and amines in neural samples and biological fluids. It is used to study fluorescent conjugates of albumin, protein conformational changes studies and active site characterization.

Safety Profile

Poison by intravenous route, When heated to decomposition it emits very toxic fumes of Cland NOx

Properties of Dansyl chloride

Melting point: 72-74 °C(lit.)
Boiling point: 371.3±22.0 °C(Predicted)
Density  1.1702 (rough estimate)
refractive index  1.5630 (estimate)
storage temp.  2-8°C
solubility  acetone: 50 mg/mL
form  powder and chunks
pka 2.38±0.40(Predicted)
color  yellow to orange
Water Solubility  Soluble in dimethyl fluoride, acetone, chloroform, pyridine, benzene and dioxane. Insoluble in water.
Sensitive  Moisture Sensitive
Merck  14,2814
BRN  2217205
Stability: Hygroscopic, Moisture Sensitive
CAS DataBase Reference 605-65-2(CAS DataBase Reference)
EPA Substance Registry System 1-Naphthalenesulfonyl chloride, 5-(dimethylamino)- (605-65-2)

Safety information for Dansyl chloride

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H290:Corrosive to Metals
H314:Skin corrosion/irritation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

Computed Descriptors for Dansyl chloride

InChIKey XPDXVDYUQZHFPV-UHFFFAOYSA-N

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