D-Mannosamine hydrochloride

Synonym(s):D-Mannosamine hydrochloride;2-Amino-2-deoxy-D-mannose hydrochloride

CAS NO.：5505-63-5
Empirical Formula: C6H14ClNO5
Molecular Weight: 215.63
MDL number: MFCD00064557
EINECS: 226-847-8
SAFETY DATA SHEET (SDS)
Update Date: 2023-10-13 18:16:27

What is D-Mannosamine hydrochloride ?

Chemical properties

D-Mannosamine hydrochloride is White Crystalline Solid

The Uses of D-Mannosamine hydrochloride

D-Mannosamine hydrochloride is a pharmaceutical compound used in the development of mannosylated liposomes for bioadhesive oral drug delivery via M cells of Peyer's patches.

The Uses of D-Mannosamine hydrochloride

D-Mannosamine hydrochloride is used in the synthesis of non-natural Mannac analogs for the expression of thiols on cell-surface sialic acids. It is also used to investigate and screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis. It acts as a precursor of N-propanoyl mannosamine and other N-acyl precursors of sialic acid (N-acyl neuraminic acids). It is a pharmaceutical compound used in the development of mannosylated liposomes for bioadhesive oral drug delivery through M cells of Peyer's patches.

The Uses of D-Mannosamine hydrochloride

D-Mannosamine hydrochloride can be used for the synthesis of non-natural ManNAc analogs for the expression of thiols on cell-surface sialic acids. It has been used in a study to investigate the synthesis and high-throughput screening of N-acetyl-β-hexosaminidase inhibitor libraries targeting osteoarthritis.

Properties of D-Mannosamine hydrochloride

Melting point:	168 °C (dec.)(lit.)
storage temp.	2-8°C
solubility	H₂O: 0.1 g/mL, clear, colorless
form	Powder
color	White to Off-white
Water Solubility	Soluble in water and methanol.
Sensitive	Hygroscopic
BRN	3914860
CAS DataBase Reference	5505-63-5(CAS DataBase Reference)
EPA Substance Registry System	D-Mannose, 2-amino-2-deoxy-, hydrochloride (5505-63-5)

Safety information for D-Mannosamine hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P330:Rinse mouth. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed.