Cynaroside
Synonym(s):Cynaroside;Luteoloside;Glucoluteolin;Glucosylluteolin;Luteolin 7-O-β-D -glucoside
- CAS NO.:5373-11-5
- Empirical Formula: C21H20O11
- Molecular Weight: 448.38
- MDL number: MFCD06799436
- EINECS: 226-365-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-09 19:38:33
What is Cynaroside?
Description
Luteolin-7-O-glucoside is a flavonoid that has been found in many Chinese herbs with diverse biological activities. It reduces lactate dehydrogenase (LDH) and caspase-3 activities and production of reactive oxygen species (ROS) and increases cell viability and 14-3-3η protein levels in H9C2 cardiomyocytes after anoxia/reoxygenation injury. Luteoloside blocks 3C protease activity (IC50 = 0.36 mM) and reduces the cytopathic effect of enterovirus 71 in rhabdomyosarcoma cells (EC50 = 0.43 mM). It inhibits the growth of hepatocellular carcinoma (HCC) cells in vitro via reduction in ROS accumulation, caspase-1 activity, and expression of the NLRP3 inflammasome and reduces the number of lung metastases in an SMMC-7721 HCC mouse xenograft model when administered at a dose of 2 mg/kg. Luteoloside also reduces acanthosis and expression of epidermal differentiation markers in a mouse model of psoriasis induced by imiquimod .
Chemical properties
Off-white powder
The Uses of Cynaroside
Luteolin 7-Glucoside is a strong antioxidant ant radical scavenger. Used in cancer prevention.
What are the applications of Application
Luteolin-7-O-D-glucopyranoside is a flavenoid
Definition
ChEBI: A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
Properties of Cynaroside
Melting point: | 256~258℃ |
storage temp. | Sealed in dry,2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
Boiling point: | 838.1±65.0 °C(Predicted) |
Density | 1.713±0.06 g/cm3(Predicted) |
form | neat |
pka | 6.10±0.40(Predicted) |
form | Solid |
color | Yellow to Very Dark Yellow |
Stability: | Hygroscopic |
CAS DataBase Reference | 5373-11-5(CAS DataBase Reference) |
Safety information for Cynaroside
Computed Descriptors for Cynaroside
InChIKey | PEFNSGRTCBGNAN-QNDFHXLGSA-N |
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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