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HomeProduct name listCynaroside

Cynaroside

Synonym(s):Cynaroside;Luteoloside;Glucoluteolin;Glucosylluteolin;Luteolin 7-O-β-D-glucoside

  • CAS NO.:5373-11-5
  • Empirical Formula: C21H20O11
  • Molecular Weight: 448.38
  • MDL number: MFCD06799436
  • EINECS: 226-365-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Cynaroside Structural

What is Cynaroside?

Description

Luteolin-7-O-glucoside is a flavonoid that has been found in many Chinese herbs with diverse biological activities. It reduces lactate dehydrogenase (LDH) and caspase-3 activities and production of reactive oxygen species (ROS) and increases cell viability and 14-3-3η protein levels in H9C2 cardiomyocytes after anoxia/reoxygenation injury. Luteoloside blocks 3C protease activity (IC50 = 0.36 mM) and reduces the cytopathic effect of enterovirus 71 in rhabdomyosarcoma cells (EC50 = 0.43 mM). It inhibits the growth of hepatocellular carcinoma (HCC) cells in vitro via reduction in ROS accumulation, caspase-1 activity, and expression of the NLRP3 inflammasome and reduces the number of lung metastases in an SMMC-7721 HCC mouse xenograft model when administered at a dose of 2 mg/kg. Luteoloside also reduces acanthosis and expression of epidermal differentiation markers in a mouse model of psoriasis induced by imiquimod .

Chemical properties

Off-white powder

The Uses of Cynaroside

Luteolin 7-Glucoside is a strong antioxidant ant radical scavenger. Used in cancer prevention.

What are the applications of Application

Luteolin-7-O-D-glucopyranoside is a flavenoid

Definition

ChEBI: A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.

Properties of Cynaroside

Melting point: 256~258℃
storage temp.  Sealed in dry,2-8°C
solubility  DMSO (Slightly), Methanol (Slightly)
Boiling point: 838.1±65.0 °C(Predicted)
Density  1.713±0.06 g/cm3(Predicted)
form  neat
pka 6.10±0.40(Predicted)
form  Solid
color  Yellow to Very Dark Yellow
Stability: Hygroscopic
CAS DataBase Reference 5373-11-5(CAS DataBase Reference)

Safety information for Cynaroside

Computed Descriptors for Cynaroside

InChIKey PEFNSGRTCBGNAN-QNDFHXLGSA-N

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