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HomeProduct name listCYFLUMETOFEN

CYFLUMETOFEN

Synonym(s):2-Methoxyethyl (RS)-2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-(α,α,α-trifluoro-o-tolyl)propionate

CYFLUMETOFEN Structural

What is CYFLUMETOFEN?

Chemical properties

Cyflumetofen is an acracide and insecticide. It has a low aqueous solubility and is non-toxic. It tends not to be persistent in the environment. Whilst its toxicity to honeybees is low it t has a moderate to high toxicity to most other biodiversity. Its oral mammalian toxicity is low.

The Uses of CYFLUMETOFEN

Cyflumetofen is a novel acaricide that only affects spider mites.

Definition

ChEBI: 2-methoxyethyl 2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate is a nitrile that is acetonitrile in which the methyl hydrogens have been replaced by o-trifluoromethylbenzoyl, p-tert-butylphenyl, and (2-methoxyethoxy)carbonyl groups. It is a nitrile, a beta-ketoester, a member of (trifluoromethyl)benzenes and a 2-methoxyethyl ester.

Biological Activity

It has been shown to inhibit the activity of detoxification enzymes and mitochondrial membrane potential, which may be responsible for its toxicity in insects. Cyflumetofen also causes a synergic effect with other chemicals, such as pesticides, by increasing their toxicity to insects.

Mechanism of action

cyflumetofen inhibited mitochondria complex II in mites. In addition, the de-esterified form (AB-1) of cyflumetofen inhibited mitochondria complex II at extremely low concentrations. AB-1 was also detected as the main metabolite in mites. The mode of action of cyflumetofen is to inhibit mitochondria complex II by affecting its action site after being metabolised to AB-1. However, inhibition by cyflumetofen and AB-1 in other organisms was very weak. Selectivity for other organisms has contributed to differences in action site activities.

Properties of CYFLUMETOFEN

Boiling point: 533.8±50.0 °C(Predicted)
Density  1.214
solubility  DMSO (Slightly), Methanol (Slightly)
form  neat
BRN  11332768
EPA Substance Registry System Benzenepropanoic acid, .alpha.-cyano-.alpha.-[4-(1,1-dimethylethyl)phenyl]-.beta.-oxo-2-(trifluoromethyl)-, 2-methoxyethyl ester (400882-07-7)

Safety information for CYFLUMETOFEN

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H317:Sensitisation, Skin
H351:Carcinogenicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for CYFLUMETOFEN

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