Cyclopropylmagnesium bromide

CAS NO.：23719-80-4
Empirical Formula: C3H5BrMg
Molecular Weight: 145.28
MDL number: MFCD00672094
EINECS: 472-500-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is Cyclopropylmagnesium bromide?

Chemical properties

Clear colorless solution

The Uses of Cyclopropylmagnesium bromide

Cyclopropylmagnesium bromide solution has been used in Grignard reaction that finds application as the key step in the preparation of aminopropylindenes, a chemotype of oxidosqualene cyclase (OSC) inhibitors from Grundmann′s ketone. It can react with trimethylborate to form cyclopropylboronic acid, which can undergo Suzuki-type coupling reactions with different aryl, and heteroaryl bromides to form the cyclopropyl adducts.

The Uses of Cyclopropylmagnesium bromide

It often acts as the starting nutrient mix for dropout studies where fermentation conditions required the absence of one or more essential amino acids. For classifying Yeasts based on colonial characteristics and cell morphology.

The Uses of Cyclopropylmagnesium bromide

Grignard reagent in greener solvent, 2-methyltetrahydrofuran (2-MeTHF)

2-Methyltetrahydrofuran (2-MeTHF): A Biomass-Derived Solvent with Broad Application in Organic Chemistry

General Description

This product, 1.0 M in 2-methyltetrahydrofuran aligns with Safer Solvents and Auxiliaries, Use of Renewable Feedstocks and Inherently Safer Chemistry for Accident Prevention.

Properties of Cyclopropylmagnesium bromide

Boiling point:	65 °C
Density	0.968 g/mL at 25 °C
Flash point:	65°C
storage temp.	2-8°C
form	Turbid Liquid
color	Yellow to green
Water Solubility	Soluble in water (17 mg/ml), (25°C). Soluble in organic solvents.
Sensitive	Air & Moisture Sensitive
CAS DataBase Reference	23719-80-4(CAS DataBase Reference)

Safety information for Cyclopropylmagnesium bromide

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H225:Flammable liquids H260:Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases H261:Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases H302:Acute toxicity,oral H313:Acute toxicity,dermal H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation H333:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H351:Carcinogenicity H371:Specific target organ toxicity, single exposure H372:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P223:Keep away from any possible contact with water, because of violent reaction and possible flash fire. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P231+P232:Handle under inert gas. Protect from moisture. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P335+P334:Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P402+P404:Store in a dry place. Store in a closed container. P403+P235:Store in a well-ventilated place. Keep cool.