Cyclopentyl methyl ether

Synonym(s):CMPE;CPME

CAS NO.：5614-37-9
Empirical Formula: C6H12O
Molecular Weight: 100.16
MDL number: MFCD08276401
EINECS: 445-090-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:15:32

What is Cyclopentyl methyl ether?

Description

Cyclopentyl methyl ether (CPME) is a useful alternative solvent to THF, 2-MeTHF, dioxane, and other ether solvents due to desirable properties such as a high boiling point, low formation of peroxides, and relative stability under acidic and basic conditions.

Chemical properties

Clear liquid

The Uses of Cyclopentyl methyl ether

Cyclopentyl methyl ether (CPME) is an alternative to ether solvents such as THF, diethyl ether, and MTBE with a higher resistance to peroxide formation. The more environmentally conservative CPME solvent replaces hazardous solvents in order to achieve sustainability and reduce environmental and operational costs. CPME offers considerable potential and advantage as a direct replacement for CH2Cl2 in binary eluents using MeOH as the modifier with MeOH-DMC and i-PrOH-EtOAc.

The Uses of Cyclopentyl methyl ether

Cyclopentyl methyl ether is a hydrophobic ether solvent widely used in Grignard reaction, Friedel-Crafts reaction, Claisen condensation and Beckmann reaction. It plays an important role in extraction and polymerization reactions as well as in surface coatings. It is considered as a replacement for tetrahydrofuran, methyl tert-butyl ether, dioxane and other existing ether solvents due to its excellent properties like high boiling point and relative stability under acidic and basic conditions.

The Uses of Cyclopentyl methyl ether

Greener alternative solvent in reactions containing the following reagents:

Alkali agents
Lewis acid-mediated reactions
Organometallic
Reduction and Oxidation
Transition metal catalysts
Azeotropic water removal

Can also be used in extraction, polymerization, crystallization and surface coatings.

The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent.

General Description

Cyclopentyl methyl ether (CPME) is a greener alternative to other ethereal solvents such as tetrahydrofuran (THF), 2-methyl tetrahydrofuran (2-MeTHF), dioxane (carcinogenic), tert-Butyl methyl ether (MTBE), and 1,2-dimethoxyethane (DME) and thus has been enhanced for "Safer Solvents and Auxiliaries".

Flammability and Explosibility

Highly flammable

Properties of Cyclopentyl methyl ether

Melting point:	-140°C
Boiling point:	106°C
Density	0.86
vapor pressure	59.9 hPa (25 °C)
refractive index	1.4210
Flash point:	-1°C(lit.)
storage temp.	Store below +30°C.
solubility	Chloroform (Sparingly), Methanol (Slightly)
appearance	Colorless liquid
form	Liquid
color	APHA: ≤10
explosive limit	1.10-9.90%
Water Solubility	Miscible with water, alcohols, ketones and hydrocarbons.
Stability:	Volatile
EPA Substance Registry System	Cyclopentane, methoxy- (5614-37-9)

Safety information for Cyclopentyl methyl ether

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.