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HomeProduct name listCYCLOOCTANONE

CYCLOOCTANONE

  • CAS NO.:502-49-8
  • Empirical Formula: C8H14O
  • Molecular Weight: 126.2
  • MDL number: MFCD00001754
  • EINECS: 207-940-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
CYCLOOCTANONE Structural

What is CYCLOOCTANONE?

Chemical properties

colorless to white crystalline low melting solid

The Uses of CYCLOOCTANONE

Cyclooctanone is a aliphatic cycle that exhibited inhibitory activity towards aldosterone synthase, a promising therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone level.

The Uses of CYCLOOCTANONE

Cyclooctanone is a aliphatic cycle that exhibited inhibitory activity towards aldosterone synthase, a promising therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone level. It is also used in the synthesis of 14-membered lactones.

Synthesis Reference(s)

Journal of the American Chemical Society, 92, p. 5276, 1970 DOI: 10.1021/ja00720a078
The Journal of Organic Chemistry, 49, p. 3912, 1984 DOI: 10.1021/jo00195a007
Tetrahedron Letters, 36, p. 2921, 1995 DOI: 10.1016/0040-4039(95)00467-Q

Purification Methods

Purify the ketone by sublimation after drying with Linde type 13X molecular sieves. The semicarbazone has m 168-169o (from dioxane) [Kohler et al. J Am Chem Soc 61 1060 1939]. The oxime has m 36-37o after subliming at high vacuum or distillation and has b 128-129o /14mm. The iso-oxime has m 72-73o [Ruzicka et al. Helv Chim Acta 32 548 1949]. [Beilstein 7 III 77, 7 IV 49.]

Properties of CYCLOOCTANONE

Melting point: 32-41 °C (lit.)
Boiling point: 195-197 °C (lit.)
Density  0.958 g/mL at 25 °C (lit.)
refractive index  1.4694
Flash point: 163 °F
storage temp.  Sealed in dry,Room Temperature
solubility  15g/l
form  Crystalline Low Melting Solid
color  Colorless to white
PH 7 (15g/l, H2O, 20℃)
Water Solubility  Soluble in water at 20°C 15g/L. Soluble in acetone, alcohol, chloroform, methanol and benzene.
BRN  1280738
CAS DataBase Reference 502-49-8(CAS DataBase Reference)
EPA Substance Registry System Cyclooctanone (502-49-8)

Safety information for CYCLOOCTANONE

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

Computed Descriptors for CYCLOOCTANONE

InChIKey IIRFCWANHMSDCG-UHFFFAOYSA-N

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