CYCLOOCTANONE
- CAS NO.:502-49-8
- Empirical Formula: C8H14O
- Molecular Weight: 126.2
- MDL number: MFCD00001754
- EINECS: 207-940-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is CYCLOOCTANONE?
Chemical properties
colorless to white crystalline low melting solid
The Uses of CYCLOOCTANONE
Cyclooctanone is a aliphatic cycle that exhibited inhibitory activity towards aldosterone synthase, a promising therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone level.
The Uses of CYCLOOCTANONE
Cyclooctanone is a aliphatic cycle that exhibited inhibitory activity towards aldosterone synthase, a promising therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone level. It is also used in the synthesis of 14-membered lactones.
Synthesis Reference(s)
Journal of the American Chemical Society, 92, p. 5276, 1970 DOI: 10.1021/ja00720a078
The Journal of Organic Chemistry, 49, p. 3912, 1984 DOI: 10.1021/jo00195a007
Tetrahedron Letters, 36, p. 2921, 1995 DOI: 10.1016/0040-4039(95)00467-Q
Purification Methods
Purify the ketone by sublimation after drying with Linde type 13X molecular sieves. The semicarbazone has m 168-169o (from dioxane) [Kohler et al. J Am Chem Soc 61 1060 1939]. The oxime has m 36-37o after subliming at high vacuum or distillation and has b 128-129o /14mm. The iso-oxime has m 72-73o [Ruzicka et al. Helv Chim Acta 32 548 1949]. [Beilstein 7 III 77, 7 IV 49.]
Properties of CYCLOOCTANONE
Melting point: | 32-41 °C (lit.) |
Boiling point: | 195-197 °C (lit.) |
Density | 0.958 g/mL at 25 °C (lit.) |
refractive index | 1.4694 |
Flash point: | 163 °F |
storage temp. | Sealed in dry,Room Temperature |
solubility | 15g/l |
form | Crystalline Low Melting Solid |
color | Colorless to white |
PH | 7 (15g/l, H2O, 20℃) |
Water Solubility | Soluble in water at 20°C 15g/L. Soluble in acetone, alcohol, chloroform, methanol and benzene. |
BRN | 1280738 |
CAS DataBase Reference | 502-49-8(CAS DataBase Reference) |
EPA Substance Registry System | Cyclooctanone (502-49-8) |
Safety information for CYCLOOCTANONE
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for CYCLOOCTANONE
InChIKey | IIRFCWANHMSDCG-UHFFFAOYSA-N |
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