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HomeProduct name listCYCLOBARBITAL

CYCLOBARBITAL

  • CAS NO.:52-31-3
  • Empirical Formula: C12H16N2O3
  • Molecular Weight: 236.27
  • MDL number: MFCD00059173
  • EINECS: 200-138-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-15 10:44:00
CYCLOBARBITAL Structural

What is CYCLOBARBITAL?

Originator

Cyclobarbital,Bayer

The Uses of CYCLOBARBITAL

Cyclobarbital has been used as an anesthetic and sedative. Controlled substance (depressant).

Definition

ChEBI: Cyclobarbital is a member of barbiturates.

Manufacturing Process

772.0 g of δ-1,2-cyclohexenylcyanacetic acid ethyl ester are introduced into astirred and ice cooled solution of 92.0 g of sodium in 1500 ml of absolutealcohol. The sodium δ-1,2-cyclohexenylcyanacetic acid ester formed is thengradually treated without ice cooling with 750.0 g of ethyl iodide. The reactionmixture become warm, sodium iodide separates out and the whole is neutralafter a short time. The sodium iodide is filtered off, the filtrate freed fromalcohol by distillation, the residues taken up in water, siphoned off, dried overcalcium chloride and distilled in vacuum, yields δ-1,2-cyclohexenylethylcyanacetic acid ethyl ester, boil point 125°C. 72.0 g ofsodium are dissolved in 1086.0 g of absolute alcohol and boiled for 3.75 hwith 285.0 g of guanidine sulfate, then 221.0 g of δ-1,2-cyclohexenylethylcyanacetic acid ester are added and boiling is continued for afurther 12 h. The residue remaining after distilling off the alcohol is boiledwith 10 times its weight of dilute sulfuric acid and then δ-1,2-cyclohexenylethylbarbituric acid which separates out is recrystallized from hotwater, melting point 170°C

brand name

Phanodorn (Sterling Winthrop).

Therapeutic Function

Hypnotic

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: pulmonary consolidation. Used as a central nervous system depressant, hypnotic, and sedative. When heated to decomposition it emits toxic fumes of NOx. See also BARBITURATES.

Properties of CYCLOBARBITAL

Melting point: 171-174°
Boiling point: 378.73°C (rough estimate)
Density  1.1623 (rough estimate)
refractive index  1.5460 (estimate)
solubility  Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka 8.03±0.10(Predicted)
form  Solid
color  White to Off-White
Water Solubility  8.27g/L(25 ºC)

Safety information for CYCLOBARBITAL

Computed Descriptors for CYCLOBARBITAL

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