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HomeProduct name listCYCLO(-HIS-PRO)

CYCLO(-HIS-PRO)

CYCLO(-HIS-PRO) Structural

What is CYCLO(-HIS-PRO)?

The Uses of CYCLO(-HIS-PRO)

Cyclo(L-histidyl-L-proline) is used in the pharmaceutical composition comprising cyclo(His-Pro) for preventing or treating obesity.

What are the applications of Application

Cyclo(-His-Pro) is a cyclic dipeptide containing histidine and proline

Definition

ChEBI: Cyclo(L-His-L-Pro) is a homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH). It has a role as a human blood serum metabolite, a dopamine uptake inhibitor and an anti-inflammatory agent. It is a homodetic cyclic peptide, a dipeptide, a pyrrolopyrazine and a member of imidazoles. It is functionally related to a L-histidine and a L-proline.

Properties of CYCLO(-HIS-PRO)

Melting point: 162-164 °C
Boiling point: 659.3±48.0 °C(Predicted)
Density  1.41±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml
form  A neat oil
pka 12.73±0.40(Predicted)
color  Light yellow to yellow

Safety information for CYCLO(-HIS-PRO)

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for CYCLO(-HIS-PRO)

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