CYCLO(-HIS-PRO)
- CAS NO.:53109-32-3
- Empirical Formula: C11H14N4O2
- Molecular Weight: 234.25
- MDL number: MFCD00133207
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:23
What is CYCLO(-HIS-PRO)?
The Uses of CYCLO(-HIS-PRO)
Cyclo(L-histidyl-L-proline) is used in the pharmaceutical composition comprising cyclo(His-Pro) for preventing or treating obesity.
What are the applications of Application
Cyclo(-His-Pro) is a cyclic dipeptide containing histidine and proline
Definition
ChEBI: Cyclo(L-His-L-Pro) is a homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH). It has a role as a human blood serum metabolite, a dopamine uptake inhibitor and an anti-inflammatory agent. It is a homodetic cyclic peptide, a dipeptide, a pyrrolopyrazine and a member of imidazoles. It is functionally related to a L-histidine and a L-proline.
Properties of CYCLO(-HIS-PRO)
Melting point: | 162-164 °C |
Boiling point: | 659.3±48.0 °C(Predicted) |
Density | 1.41±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml |
form | A neat oil |
pka | 12.73±0.40(Predicted) |
color | Light yellow to yellow |
Safety information for CYCLO(-HIS-PRO)
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CYCLO(-HIS-PRO)
New Products
Tubulysin G Tubulysin D Tubulysin C Tubulysin M 4,4-DIFLUOROPIPERIDINE 2H-Pyran, 4-ethynyltetrahydro- 3-N-BOC-(S)-AMINO BUTYRONITRILE 3-Aminocyclobutanone hydrochloride 1-(1,1-Difluoroethyl)-2-fluorobenzene 4,4-DIFLUOROCYCLOHEXANAMINE Fuel shell Imeglimin Hydrochloride IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
CYCLO(-HIS-PRO)
1-Methylpiperazin-2-one
2,5-Dimethylpiperazine
1-ETHYLPIPERAZIN-2-ONE
(R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE
(+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE
HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE
CYCLO(-ALA-ALA)
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