CYANOMETHYLENETRIBUTYLPHOSPHORANE

Synonym(s):(Cyanomethylene)tributylphosphorane

CAS NO.：157141-27-0
Empirical Formula: C14H28NP
Molecular Weight: 241.35
MDL number: MFCD01321151
SAFETY DATA SHEET (SDS)
Update Date: 2023-10-27 17:04:05

CYANOMETHYLENETRIBUTYLPHOSPHORANE Structural

What is CYANOMETHYLENETRIBUTYLPHOSPHORANE?

The Uses of CYANOMETHYLENETRIBUTYLPHOSPHORANE

(Tributylphosphoranylidene)acetonitrile can be utilized as a reagent in the:

Stereoselective synthesis of skytanthine and other O- and N-containing heterocycles by Mitsunobu intramolecular cycloalkylation.
Wittig olefination of esters, lactones, N-Boc lactam, and cyclic imide to corresponding Wittig products.

General Description

(Tributylphosphoranylidene)acetonitrile is a stabilized trialkylphosphorane that can act as a substitute to the diethyl azodicarboxylate and triphenylphosphine (DEAD-TPP) system for Mitsunobu reaction between nucleophiles (HA) and alcohols (ROH) to form RA. It is highly useful when the pKa of the nucleophiles are higher than 11.

Properties of CYANOMETHYLENETRIBUTYLPHOSPHORANE

Boiling point:	339.1±25.0 °C(Predicted)
Density	0.921 g/mL at 25 °C
refractive index	n20/D1.500(lit.)
Flash point:	7 °C
storage temp.	2-8°C
form	clear liquid
color	Yellow to Amber to Dark purple

Safety information for CYANOMETHYLENETRIBUTYLPHOSPHORANE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to..…