CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
Synonym(s):1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine
- CAS NO.：215923-54-9
- Empirical Formula: C14H17NO3
- Molecular Weight: 247.29
- MDL number: MFCD01860868
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P?
The Uses of CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
It is one of a series of AMPA modulators matergic AMPA receptors.
The Uses of CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.
What are the applications of Application
CX546 is an AMPA receptor potentiator and GluR activator
General Description
CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.
Biological Activity
AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats.
Biochem/physiol Actions
CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI)?in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.
storage
Store at +4°C
Properties of CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
| Melting point: | 71-73°C |
| Boiling point: | 422.8±44.0 °C(Predicted) |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥10mg/mL |
| pka | -1.08±0.20(Predicted) |
| form | solid |
| color | white to off-white |
Safety information for CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
Computed Descriptors for CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
New Products
Tubulysin D Tubulysin H (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride 4,4-DIFLUOROCYCLOHEXANAMINE 2,2-Difluoropropylamine hydrochloride CYCLOBUTYLAMINE HYDROCHLORIDE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 4-(Benzyloxy)-3-bromophenylacetic Acid 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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