Cytidine triphosphate
- CAS NO.:65-47-4
- Empirical Formula: C9H16N3O14P3
- Molecular Weight: 483.16
- MDL number: MFCD00047493
- EINECS: 200-611-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-28 13:53:25
What is Cytidine triphosphate?
Description
Cytidine 5′-triphosphate (CTP) is a pyrimidine nucleoside triphosphate that is analogous to the better-known ATP, but with cytidine as the base instead of adenine. It is a substrate in the biosynthesis of RNA.
Triphosphates like CTP and ATP are high-energy molecules; but ATP is involved in many more metabolic reactions than CTP. Now, however, CTP may be useful in the development of new antiviral drugs.
The research groups of biochemists Steven C. Almo at the Albert Einstein College of Medicine (Bronx, NY) and Craig Cameron at Penn State (University Park, PA) discovered that an enzyme expressed in humans catalyzes the dehydration of CTP to produce another triphosphate abbreviated as ddhCTP. The dehydrated species resembles current antivirals that disrupt RNA genome replication in some viruses.
In in vitro experiments, the researchers found that ddhCTP inhibits RNA polymerases in viruses such as Zika, West Nile, dengue, and hepatitis C. In addition to the possibility of developing new antivirals by using this technique, experts predict that this research could open new pathways to drugs based on natural small molecules.
Definition
ChEBI: CTP is a pyrimidine ribonucleoside 5'-triphosphate and a cytidine 5'-phosphate. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a CTP(4-) and a CTP(3-).
Properties of Cytidine triphosphate
Melting point: | 215–218 oc |
storage temp. | 2-8°C |
solubility | 11.2 g/l |
form | Solid |
appearance | white powder |
color | White to off-white |
EPA Substance Registry System | Cytidine 5'-(tetrahydrogen triphosphate) (65-47-4) |
Safety information for Cytidine triphosphate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Cytidine triphosphate
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