2'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE LITHIUM SALT

CAS NO.：2056-98-6
Empirical Formula: C9H16N3O13P3
Molecular Weight: 467.16
MDL number: MFCD00135938
EINECS: 218-153-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-20 11:41:24

What is 2'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE LITHIUM SALT?

The Uses of 2'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE LITHIUM SALT

Isotope labelled 2’-Deoxycytidine 5’-Triphosphate Triethylamine, a labelled metabolite of 2’-Deoxycytidine, a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction.

Definition

ChEBI: DCTP is a 2'-deoxycytidine phosphate having cytosine as the nucleobase. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a 2'-deoxycytidine phosphate and a pyrimidine 2'-deoxyribonucleoside 5'-triphosphate. It is a conjugate acid of a dCTP(3-).

Biological Activity

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used in DNA synthesis. Deoxycytidine triphosphate can be used in real-time PCR, cDNA synthesis and DNA sequencing research.

in vitro

Assays of thirteen cell lines, derived from mouse lymphomas, myelomas, myeloid tumors, and a mastocytoma, for sensitivity to growth inhibition by 1-β-D-arabinofuranosylcytosine (ara-C) revealed a spectrum between the most and least sensitive which differed 100-fold from each other. An inverse correlation between sensitivity and cellular Deoxycytidine triphosphate (2′-Deoxycytidine-5′-triphosphate, dCTP) content is found, and this suggested that sensitivity of cells might be increased if the dCTP content was lowered during cell exposure to ara-C.
Deoxycytidine triphosphate trisodium salt is a phosphoethanolamine cytidylyltransferase substrate.

Properties of 2'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE LITHIUM SALT

Boiling point:	811.5±75.0 °C(Predicted)
Density	2.38±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	0.80±0.50(Predicted)
form	Stabilized Aqueous Solution
color	White to off-white
Water Solubility	Water : ≥ 35 mg/mL (74.92 mM)

Safety information for 2'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE LITHIUM SALT

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.