Coumarin 151
Synonym(s):Coumarin 151
- CAS NO.:53518-15-3
- Empirical Formula: C10H6F3NO2
- Molecular Weight: 229.16
- MDL number: MFCD00006858
- EINECS: 258-599-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 08:26:49
What is Coumarin 151?
Chemical properties
Coumarin 151 is yellow powder
The Uses of Coumarin 151
Coumarin 151 is used to prepare peptidase substrates and for the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids.
The Uses of Coumarin 151
7-Amino-4-(trifluoromethyl)coumarin is used in the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids. It is suitable as laser dye.
What are the applications of Application
7-Amino-4-trifluoromethylcoumarin is for the fluorometric assay of proteolytic enzymes in biological fluids
Definition
ChEBI: 7-amino-4-(trifluoromethyl)coumarin is a member of 7-aminocoumarins. It has a role as a fluorochrome.
Purification Methods
Purify the coumarin by column chromatography on a C18 column, elute with acetonitrile/0.01M H2O/HCl (1:1), and recrystallise it from isopropanol. Alternatively, it is eluted from a silica gel column with CH2Cl2, or by extracting a CH2Cl2 solution (4g/L) with 1M aqueous NaOH (3 x 0.1L), followed by drying (MgSO4), filtration and evaporation. [Bissell J Org Chem 45 2283 1980, Zimmermann et al. Anal Biochem 70 258 1976.]
Properties of Coumarin 151
Melting point: | 221-222 °C(lit.) |
Boiling point: | 314.6±42.0 °C(Predicted) |
Density | 1.4096 (estimate) |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
form | Powder |
pka | 1.12±0.20(Predicted) |
color | Yellow |
Water Solubility | Soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water. |
BRN | 4456797 |
CAS DataBase Reference | 53518-15-3(CAS DataBase Reference) |
EPA Substance Registry System | 2H-1-Benzopyran-2-one, 7-amino-4-(trifluoromethyl)- (53518-15-3) |
Safety information for Coumarin 151
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Coumarin 151
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