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HomeProduct name listCoumarin 151

Coumarin 151

Synonym(s):Coumarin 151

  • CAS NO.:53518-15-3
  • Empirical Formula: C10H6F3NO2
  • Molecular Weight: 229.16
  • MDL number: MFCD00006858
  • EINECS: 258-599-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 08:26:49
Coumarin 151 Structural

What is Coumarin 151?

Chemical properties

Coumarin 151 is yellow powder

The Uses of Coumarin 151

Coumarin 151 is used to prepare peptidase substrates and for the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids.

The Uses of Coumarin 151

7-Amino-4-(trifluoromethyl)coumarin is used in the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids. It is suitable as laser dye.

What are the applications of Application

7-Amino-4-trifluoromethylcoumarin is for the fluorometric assay of proteolytic enzymes in biological fluids

Definition

ChEBI: 7-amino-4-(trifluoromethyl)coumarin is a member of 7-aminocoumarins. It has a role as a fluorochrome.

Purification Methods

Purify the coumarin by column chromatography on a C18 column, elute with acetonitrile/0.01M H2O/HCl (1:1), and recrystallise it from isopropanol. Alternatively, it is eluted from a silica gel column with CH2Cl2, or by extracting a CH2Cl2 solution (4g/L) with 1M aqueous NaOH (3 x 0.1L), followed by drying (MgSO4), filtration and evaporation. [Bissell J Org Chem 45 2283 1980, Zimmermann et al. Anal Biochem 70 258 1976.]

Properties of Coumarin 151

Melting point: 221-222 °C(lit.)
Boiling point: 314.6±42.0 °C(Predicted)
Density  1.4096 (estimate)
storage temp.  under inert gas (nitrogen or Argon) at 2–8 °C
form  Powder
pka 1.12±0.20(Predicted)
color  Yellow
Water Solubility  Soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water.
BRN  4456797
CAS DataBase Reference 53518-15-3(CAS DataBase Reference)
EPA Substance Registry System 2H-1-Benzopyran-2-one, 7-amino-4-(trifluoromethyl)- (53518-15-3)

Safety information for Coumarin 151

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Coumarin 151

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