CONESSINE
Synonym(s):(3β)-N,N-dimethyl-con-5-enin-3-amine;Conessin;Neriine;Roquessine;Wrightine
- CAS NO.:546-06-5
- Empirical Formula: C24H40N2
- Molecular Weight: 356.59
- MDL number: MFCD00016752
- EINECS: 208-897-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 08:26:49
What is CONESSINE?
Description
Conessine is a naturally occurring steroid alkaloid found in a number of plant species from the Apocynaceae family, which have been used in traditional herbal medicine as a treatment for amoebic dysentery. In a radioligand-
The Uses of CONESSINE
Conessine is a steroidal dibasic alkaloid with a rigid steroid-based skeleton. Conessine is a potent and selective histamine H3 receptor antagonist.
The Uses of CONESSINE
antiamebic, antibacterial, antineoplastic, anesthetic (local)
What are the applications of Application
Conessine is a selective antagonist at the histamine H3-receptor
Definition
ChEBI: A steroid alkaloid that is con-5-enine substituted by a N,N-dimethylamino group at position 3. It has been isolated from the plant species of the family Apocynaceae.
Biological Activity
Potent and selective histamine H 3 receptor antagonist (pK i values are 7.61 and 8.27 at rat and human H 3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC 50 = 1.04 μ M). Also has high affinity for α 2C adrenoceptors (pK i = 7.98).
Purification Methods
It crystallises from acetone, sublimes at 95o/0.01mm and boils at 0.1mm with bath temperature at 220o. The dihydrochloride has m >340o (browns at 235o and decomposes at 338-240o) and has [] D +9.3o (c 2, H2O). [Marshall & Johnson J Am Chem Soc 84 1458 1962, Beilstein 22 III/IV 4382.]
Properties of CONESSINE
Melting point: | 126-127°C |
alpha | D20 +25.3° (c = 0.7 in abs alc) |
Boiling point: | 479.38°C (rough estimate) |
Density | 0.9492 (rough estimate) |
refractive index | 1.5640 (estimate) |
storage temp. | Store at RT |
solubility | ethanol: ≥2mg/mL |
pka | 10.20±0.70(Predicted) |
form | powder |
color | white to tan |
Safety information for CONESSINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CONESSINE
Abamectin manufacturer
CHROMOSYNTH PVT LTD
AVIGYABIOSCIENCES PRIVATE LIMITED
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