Concanavalin A
Synonym(s):Con A;Con A, Jack Bean Hemagglutinin;ConA;Concanavalin A, Canavalia ensiformis
- CAS NO.:11028-71-0
- Empirical Formula: C15H24
- Molecular Weight: 0
- MDL number: MFCD00071069
- EINECS: 234-258-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-08 18:06:34
What is Concanavalin A?
Chemical properties
Lyophilized
The Uses of Concanavalin A
Concanavalin A is a unique lectin purified from the jack bean, C. ensiformis, that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis. Concanavalin A specifically binds to α-mannose and α-galactose structures found in sugars, glycoproteins, and glycolipids and has been used in affinity chromatography purifications of various glycoproteins and cellular structures. At 20 mg/kg concanavalin A is also used to induce liver injury in experimental mouse models of autoimmune hepatitis in order to study immune regulation by macrophages and T cells. Concanavalin A is toxic to several tumor cell lines and has been reported to induce programmed cell death of cortical neurons by a mechanism similar to that of the amyloid β peptide.
The Uses of Concanavalin A
As a reagent in analytical and preparative biochemistry; as a probe in studies of cell surface membrane dynamics and cell division.
The Uses of Concanavalin A
Concanavalin A is a plant lectin that is a T-cell mitogen, and induces apoptosis in human fibroblasts.
What are the applications of Application
Concanavalin A is a compound that induces apoptosis
Definition
A lectin mitogen that binds specifically to and agglutinates transforms into tumors. It binds to glucose and mannose residues in the surface.
General Description
Concanavalin A is a protein containing only β-sheets in its structure, and belongs to the legume lectins family.
Hazard
Poison; teratogen; mutagen.
Biochem/physiol Actions
Concanavalin A is known to stimulate acute hepatic inflammation and acts as a T‐cell mitogen. It has inhibitory effect on hepatocellular carcinoma by inducing autophagy.
storage
-20°C
Properties of Concanavalin A
Flash point: | 39 °C |
storage temp. | -20°C |
solubility | PBS: 5 mg/mL, slightly hazy |
form | powder |
color | White to light yellow |
Water Solubility | Slightly soluble in water and phosfate buffered saline. |
CAS DataBase Reference | 11028-71-0 |
Safety information for Concanavalin A
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H317:Sensitisation, Skin H334:Sensitisation, respiratory H361:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Concanavalin A
Concanavalin A manufacturer
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid DIETHYL AMINOMALONATE HYDROCHLORIDE 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
You may like
-
Concanavalin A, from Canavalia ensiformis (Jack bean) Type IV, lyophilized powder CAS 11028-71-0View Details
11028-71-0 -
Concanavalin A Lectin ex. Canavalia Ensiformis Type 1 for cell culture CAS 11028-71-0View Details
11028-71-0 -
Concanavalin A, from canavalia ensiformis (jack bean) CAS 11028-71-0View Details
11028-71-0 -
Concanavalin A from Canavalia ensiformis (Jack bean) CASView Details
-
Concanavalin A from Canavalia ensiformis (Jack bean) CASView Details
-
Concanavalin A from Canavalia ensiformis (Jack bean) CASView Details
-
Concanavalin A from Canavalia ensiformis (Jack bean) CASView Details
-
Concanavalin A from Canavalia ensiformis (Jack bean) CASView Details