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HomeProduct name listCOCHLIOQUINONE A

COCHLIOQUINONE A

COCHLIOQUINONE A Structural

What is COCHLIOQUINONE A?

The Uses of COCHLIOQUINONE A

Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. Cochlioquinone A has recently been shown to be an antagonist of the human chemokine receptor, CCR5, in HIV-1,). Cochlioquinone A is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH-ubiquinone reductase.

The Uses of COCHLIOQUINONE A

Cochlioquinone A, a bioactive compound isolated from D. sacchari and Bipolaris sp., is an inhibitor of diacylglycerol kinase (DGK; Ki = 3.1 μM) and diacylglycerol acyltransferase (DGAT; IC50 = 5.6 μM). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma with an IC50 value of 3 μM. It is also reported to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors with an IC50 value of 11 μM.[Cayman Chemical]

The Uses of COCHLIOQUINONE A

Cochlioquinone A is an antagonist of CCR5. Diacylglycerol kinase inhibitor.

What are the applications of Application

Cochlioquinone A is an antagonist of CKR-5 (CCR5)

Definition

ChEBI: Cochlioquinone A is a member of oxanes.

Properties of COCHLIOQUINONE A

Melting point: 135 °C
Boiling point: 638.8±55.0 °C(Predicted)
Density  1.21±0.1 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form  A yellow lyophilisate
pka 11.57±0.70(Predicted)

Safety information for COCHLIOQUINONE A

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for COCHLIOQUINONE A

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