COCHLIOQUINONE A
- CAS NO.:32450-25-2
- Empirical Formula: C30H44O8
- Molecular Weight: 532.67
- MDL number: MFCD08062299
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:02:40
What is COCHLIOQUINONE A?
The Uses of COCHLIOQUINONE A
Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. Cochlioquinone A has recently been shown to be an antagonist of the human chemokine receptor, CCR5, in HIV-1,). Cochlioquinone A is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH-ubiquinone reductase.
The Uses of COCHLIOQUINONE A
Cochlioquinone A, a bioactive compound isolated from D. sacchari and Bipolaris sp., is an inhibitor of diacylglycerol kinase (DGK; Ki = 3.1 μM) and diacylglycerol acyltransferase (DGAT; IC50 = 5.6 μM). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma with an IC50 value of 3 μM. It is also reported to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors with an IC50 value of 11 μM.[Cayman Chemical]
The Uses of COCHLIOQUINONE A
Cochlioquinone A is an antagonist of CCR5. Diacylglycerol kinase inhibitor.
What are the applications of Application
Cochlioquinone A is an antagonist of CKR-5 (CCR5)
Definition
ChEBI: Cochlioquinone A is a member of oxanes.
Properties of COCHLIOQUINONE A
Melting point: | 135 °C |
Boiling point: | 638.8±55.0 °C(Predicted) |
Density | 1.21±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble |
form | A yellow lyophilisate |
pka | 11.57±0.70(Predicted) |
Safety information for COCHLIOQUINONE A
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for COCHLIOQUINONE A
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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